| + |
Starvation | up-regulates activity 
|
SIRT1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15744310 |
We show here that the Sir2 homologue, SIRT1—which modulates ageing in several species —controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α. A nutrient signalling response that is mediated by pyruvate induces SIRT1 protein in liver during fasting. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| Pathways: | AMPK Signaling |
| + |
Starvation | up-regulates
|
AMPK |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000343 |
Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activationSTARV |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209894 |
|
|
Homo sapiens |
Myotube |
| pmid |
sentence |
| 20810907 |
L6 myotubes were incubated in serum-containing or serum-free medium for 3 h. Levels of phosphorylated AMPK, Akt, and ATM were greater in serum-starved cells than in control cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
3.0
Starvation