Crohn_Lymphocyte

Pathway ID: SIGNOR-CROHN_LYMPHOCYTE

Description: In Crohn's disease, IL-12 production by antigen-presenting cells (APCs) in lymphocytes promotes Th1 development through the transcription factors STAT4 and T-bet, with IFN-γ production, while inflammatory cytokines such as IL-1, IL-6, and IL-23 direct maturation towards Th17.

Curated by: Luana Tiberia

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33 Seed Entities

Organism:
Name Primary ID
IL10 P22301
IL12A P29459
IFNGR2 P38484
STAT4 Q14765
IL4 P05112
TGFB1 P01137
SMAD2/STAT3/EP300 SIGNOR-C203
FOXP3 Q9BZS1
Th17 SIGNOR-PH94
GATA3 P23771
IL6ST P40189
Proliferation SIGNOR-PH4
IFNGR2/INFGR1 SIGNOR-C142
SMAD2 Q15796
Immune_response SIGNOR-PH17
Inflammation SIGNOR-PH12
RORC P51449
CD3 SIGNOR-C432
T-reg_differentiation SIGNOR-PH91
TBX21 Q9UL17
9-cis-retinoic acid CHEBI:50648
T_cell_activation SIGNOR-PH73
JAK1 P23458
TCR SIGNOR-C153
IFNG P01579
ERK1/2 SIGNOR-PF1
AP1 SIGNOR-C154
SMAD3 P84022
STAT3 P40763
LCK P06239
IL6 P05231
STAT1 P42224
TGFBR1 P36897