4.0
Insulin Signaling
Pathway ID: SIGNOR-INSR
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Description: In physiological conditions, insulin controls critical energy functions such as glucose and lipid metabolism. Insulin binds and activates the insulin receptor tyrosine kinase (IR), which phosphorylates and recruits different substrate adaptors. Tyrosine phosphorylated substrates, in turn, act as scaffolds for numerous partners, initiating a signaling cascade that involve via PI3K/Akt and Ras/MAP kinase pathways.
Use SIGNOR Cytoscape App
Description: In physiological conditions, insulin controls critical energy functions such as glucose and lipid metabolism. Insulin binds and activates the insulin receptor tyrosine kinase (IR), which phosphorylates and recruits different substrate adaptors. Tyrosine phosphorylated substrates, in turn, act as scaffolds for numerous partners, initiating a signaling cascade that involve via PI3K/Akt and Ras/MAP kinase pathways.
Use SIGNOR Cytoscape App
33 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| PTEN | P60484 |
| PTPN1 | P18031 |
| MEK1/2 | SIGNOR-PF25 |
| JUN | P05412 |
| PIK3CB | P42338 |
| SREBF1 | P36956 |
| TSC1 | Q92574 |
| TSC | SIGNOR-C101 |
| GRB2 | P62993 |
| SGK1 | O00141 |
| Glycogen_synthesis | SIGNOR-PH39 |
| PDPK1 | O15530 |
| GYS1 | P13807 |
| EIF4E | P06730 |
| PIP3 | CHEBI:16618 |
| Lipogenesis | SIGNOR-PH30 |
| mTORC1 | SIGNOR-C3 |
| Protein_synthesis | SIGNOR-PH29 |
| INSR | P06213 |
| RPS6KB1 | P23443 |
| RAF1 | P04049 |
| RHEB | Q15382 |
| Proliferation | SIGNOR-PH4 |
| IRS1 | P35568 |
| EIF4EBP1 | Q13541 |
| FOXO3 | O43524 |
| ERK1/2 | SIGNOR-PF1 |
| INS | P01308 |
| PDX1 | P52945 |
| HRAS | P01112 |
| GSK3B | P49841 |
| SOS1 | Q07889 |
| AKT | SIGNOR-PF24 |