| + |
BUB1 | down-regulates activity 
phosphorylation
|
CDC20 |
0.992 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250604 |
Ser153 |
NRLKVLYsQKATPGS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250605 |
Ser161 |
QKATPGSsRKTCRYI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250606 |
Ser41 |
EAAGPAPsPMRAANR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250607 |
Ser72 |
SKVQTTPsKPGGDRY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250608 |
Ser92 |
AAQMEVAsFLLSKEN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250609 |
Thr157 |
VLYSQKAtPGSSRKT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates 
phosphorylation
|
BUB1 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177276 |
Ser314 |
SHEDLPAsQERSEVN |
Homo sapiens |
|
| pmid |
sentence |
| 22099307 |
We also demonstrate that mitotically activated atm phosphorylates bub1, a critical kinetochore protein, on ser314. Atm-mediated bub1 ser314 phosphorylation is required for bub1 activity and is essential for the activation of the spindle checkpoint |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 | up-regulates activity
phosphorylation
|
TP53 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280199 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 22852086 |
In addition, purified Bub1 directly phosphorylates p53 on Ser-37 in vitro , possibly inducing cellular senescence [ xref ].|Studies have shown that depletion and inhibition of Aurora A, Aurora B, Plk1, or Bub1 induces cellular senescence or cell death in a p53 dependent or -independent but p73 dependent manner in many different cell types , - ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 | up-regulates activity
phosphorylation
|
STAT3 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280198 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 34852826 |
This study showed that the BUB1 kinase drives the progression and proliferation of BCa by regulating the transcriptional activation of STAT3 signaling and may be an attractive candidate for therapeutic targeting in BCa.|We further identified through a series of molecular and cell biological approaches that BUB1 interacted directly with STAT3 and mediated the phosphorylation of STAT3 at Ser727. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates activity
phosphorylation
|
BUB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277186 |
Ser969 |
FTAKCETsGFQCVEM |
in vitro |
|
| pmid |
sentence |
| 26658523 |
Conversely, Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 |
phosphorylation
|
H2AC11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265261 |
Thr121 |
AVLLPKKtESHHKAK |
Homo sapiens |
|
| pmid |
sentence |
| 19965387 |
the localization of hBub1 kinase usually defines the centromere-specific phosphorylation of H2A-T120. Accordingly, hSgo1 localized along the whole chromosome length in H2B-hBub1deltaN cells (Fig. 6D), indicating that H2A-pT120 plays a predominant role in defining shugoshin localization sites on the human chromosomes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTK | up-regulates activity
phosphorylation
|
BUB1 |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278255 |
Thr461 |
SKVQPSPtVHTKEAL |
Homo sapiens |
|
| pmid |
sentence |
| 28072388 |
After Cdk1 phosphorylates Bub1 S459, Mps1 then phosphorylates Bub1 T461 (b). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
BUB1 |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147065 |
Thr609 |
SAAQLAStPFHKLPV |
Homo sapiens |
|
| pmid |
sentence |
| 16760428 |
The plk1-bub1 interaction requires the polo-box domain (pbd) of plk1 and is enhanced by cyclin-dependent kinase 1 (cdk1)-mediated phosphorylation of bub1 at t609 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates activity
phosphorylation
|
BUB1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25540073 |
Note that PLK1 phosphorylates and activates BUB1 to localize it to the kinetochore, phosphorylates and inhibits the negative regulator PKMYTI and interacts with the G1/S kinase Cdc7p to target it to initiation complexes late in G1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates quantity by stabilization
phosphorylation
|
SGO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19015261 |
Bub1 phosphorylates Sgo1 in the vicinity of its APC/C degrons in vitro.|On the other hand, Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1 mediated chromosome removal of Sgo1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates
binding
|
PLK1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147061 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16760428 |
The plk1-bub1 interaction requires the polo-box domain (pbd) of plk1 and is enhanced by cyclin-dependent kinase 1 (cdk1)-mediated phosphorylation of bub1 at t609 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates activity
relocalization
|
CENPE |
0.833 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252016 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
KNL1 | up-regulates
binding
|
BUB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17981135 |
Association of the amino and middle domain of blinkin with the tpr domains in the amino termini of bubr1 and bub1 is essential for bubr1 and bub1 to execute their distinct mitotic functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates activity
relocalization
|
MAD1L1 |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252017 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
AURKB | up-regulates activity
phosphorylation
|
BUB1 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279010 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34861183 |
Although our analysis identified only one of the 15 sites implicated in Bub1-Mad1 interaction, it suggests that following its rapamycin-induced dimerization, Ipl1 phosphorylates Bub1, and potentially Mad1, to drive eSAC signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates 
|
Mitotic_checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20888775 |
The multidomain protein kinases bub1 and bubr1 (mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (sac) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 | up-regulates activity
relocalization
|
MAD2L1 |
0.96 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252018 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
BUB1 | up-regulates activity
relocalization
|
BUB3 |
0.944 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252019 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
4.0
BUB1
- 
- 