Summary

Name TCF4
Full Name Transcription factor 4
Synonyms TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2 | BHLHB19, ITF2, SEF2
Primary ID P15884
Links - -
Type protein
Relations 16
Pathways Hepatocellular Tumor, WNT/FLT3
Function Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NRXN1 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.613
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CNTNAP2 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SSTR2 0.362
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.343
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.27
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ form complex img/form-complex.png binding MYOD/E2-2 0.692
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TCF4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.47
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.646
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding TCF4 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ up-regulates activity img/direct-activation.png binding TCF4 0.678
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, WNT/FLT3
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX9 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYC 0.376
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, WNT/FLT3
+ down-regulates img/direct_inhibition.png phosphorylation TCF4 0.2
Publications: 1 Organism: Homo Sapiens