| + |
CDK2 | up-regulates activity 
phosphorylation
|
UBTF |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235419 |
Ser389 |
INKKQATsPASKKPA |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11698641 |
Phosphorylation of ubf at serine 388 is required for interaction with rna polymerase i and activation of rdna transcription. After g(1) progression ubf is phosphorylated at serine 388 by cdk2/cyclin e and cdk2/cyclin a. Conversion of serine 388 to glycine abolishes ubf activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CyclinE/CDK2 | up-regulates
phosphorylation
|
UBTF |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216678 |
Ser389 |
INKKQATsPASKKPA |
Homo sapiens |
|
| pmid |
sentence |
| 11698641 |
Phosphorylation of ubf at serine 388 is required for interaction with rna polymerase i and activation of rdna transcription. After g(1) progression ubf is phosphorylated at serine 388 by cdk2/cyclin e and cdk2/cyclin a. Conversion of serine 388 to glycine abolishes ubf activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | up-regulates
phosphorylation
|
UBTF |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217304 |
Ser389 |
INKKQATsPASKKPA |
Homo sapiens |
|
| pmid |
sentence |
| 11698641 |
Phosphorylation of ubf at serine 388 is required for interaction with rna polymerase i and activation of rdna transcription. After g(1) progression ubf is phosphorylated at serine 388 by cdk2/cyclin e and cdk2/cyclin a. Conversion of serine 388 to glycine abolishes ubf activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinE/CDK2 | up-regulates activity
phosphorylation
|
UBTF |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250755 |
Ser484 |
ERGKLPEsPKRAEEI |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10202152 |
We have identified Ser484 as a direct target for cyclin-dependent kinase 4 (cdk4)-cyclin D1- and cdk2-cyclin E-directed phosphorylation. Mutation of Ser484 impairs rDNA transcription in vivo and in vitro. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CyclinD/CDK4 | up-regulates activity
phosphorylation
|
UBTF |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250754 |
Ser484 |
ERGKLPEsPKRAEEI |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10202152 |
We have identified Ser484 as a direct target for cyclin-dependent kinase 4 (cdk4)-cyclin D1- and cdk2-cyclin E-directed phosphorylation. Mutation of Ser484 impairs rDNA transcription in vivo and in vitro. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK1 | down-regulates 
phosphorylation
|
UBTF |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112805 |
Thr117 |
DFPKKPLtPYFRFFM |
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112809 |
Thr201 |
DIPEKPKtPQQLWYT |
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
UBTF |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112813 |
Thr117 |
DFPKKPLtPYFRFFM |
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112817 |
Thr201 |
DIPEKPKtPQQLWYT |
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
UBTF | up-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260077 |
|
|
Mus musculus |
32D Cell |
| pmid |
sentence |
| 15169904 |
Pescadillo (PES1) and the upstream binding factor (UBF1) play a role in ribosome biogenesis, which regulates cell size, an important component of cell proliferation. We have investigated the effects of PES1 and UBF1 on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3)-dependent murine myeloid cell line. Parental 32D cells and 32D IGF-IR cells (expressing increased levels of the type 1 insulin-like growth factor I [IGF-I] receptor [IGF-IR]) do not express insulin receptor substrate 1 (IRS-1) or IRS-2. 32D IGF-IR cells differentiate when the cells are shifted from IL-3 to IGF-I. Ectopic expression of IRS-1 inhibits differentiation and transforms 32D IGF-IR cells into a tumor-forming cell line. We found that PES1 and UBF1 increased cell size and/or altered the cell cycle distribution of 32D-derived cells but failed to make them IL-3 independent. PES1 and UBF1 also failed to inhibit the differentiation program initiated by the activation of the IGF-IR, which is blocked by IRS-1. 32D IGF-IR cells expressing PES1 or UBF1 differentiate into granulocytes like their parental cells. In contrast, PES1 and UBF1 can transform mouse embryo fibroblasts that have high levels of endogenous IRS-1 and are not prone to differentiation. Our results provide a model for one of the theories of myeloid leukemia, in which both a stimulus of proliferation and a block of differentiation are required for leukemia development. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, MLL fusion protein in AML |
| + |
SL1 complex | up-regulates activity
binding
|
UBTF |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269567 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15970593 |
Therefore, we propose that SL1 directs PIC formation, functioning in core promoter binding, RNA polymerase I recruitment, and UBF stabilization and that SL1-promoter complex formation is a necessary prerequisite to the assembly of functional and stable PICs that include the UBF activator in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
RB1 | down-regulates activity
binding
|
UBTF |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262589 |
|
|
in vitro |
|
| pmid |
sentence |
| 7877691 |
Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Gbeta | down-regulates
phosphorylation
|
UBTF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270080 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MXD1 | down-regulates quantity by repression
transcriptional regulation
|
UBTF |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269646 |
|
|
Homo sapiens |
Granulocyte |
| pmid |
sentence |
| 15282543 |
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation|MAD1 repressed and c-MYC activated rDNA transcription in nuclear run-on assays. Repression of rDNA transcription by MAD1 was associated with its ability to interact directly with the promoter of upstream binding factor (UBF), an rDNA regulatory factor. Conversely, c-MYC activated transcription from the UBF promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF6 | down-regulates
binding
|
UBTF |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200133 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23229552 |
We demonstrate that phf6 is a nucleolus, ribosomal rna promoter-associated protein. Phf6 directly interacts with upstream binding factor (ubf) through its phd1 domain and suppresses ribosomal rna (rrna) transcription by affecting the protein level of ubf |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, MLL fusion protein in AML |
| + |
ERK1/2 | down-regulates
phosphorylation
|
UBTF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270181 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11741541 |
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
UBTF | up-regulates activity
binding
|
RNA Polymerase I |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15970593 |
Therefore, we propose that SL1 directs PIC formation, functioning in core promoter binding, RNA polymerase I recruitment, and UBF stabilization and that SL1-promoter complex formation is a necessary prerequisite to the assembly of functional and stable PICs that include the UBF activator in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
UBTF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269644 |
|
|
Homo sapiens |
Granulocyte |
| pmid |
sentence |
| 15282543 |
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation|MAD1 repressed and c-MYC activated rDNA transcription in nuclear run-on assays. Repression of rDNA transcription by MAD1 was associated with its ability to interact directly with the promoter of upstream binding factor (UBF), an rDNA regulatory factor. Conversely, c-MYC activated transcription from the UBF promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, MLL fusion protein in AML |
| + |
UBTF | up-regulates quantity by expression
transcriptional regulation
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262590 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 7877691 |
Rb specifically inhibits the activity of the RNA polymerase I transcription factor UBF (upstream binding factor) in vitro. |These results indicate that there is an additional mechanism by which Rb suppresses cell growth, namely that Rb directly represses transcription of the rRNA genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
3.0
UBTF
- 
- 