| + |
MAPK3 | down-regulates 
phosphorylation
|
TAL1 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116153 |
Ser122 |
DGRMVQLsPPALAAP |
Homo sapiens |
|
| pmid |
sentence |
| 11904294 |
We report here that the important proangiogenic stimulus hypoxia stimulates phosphorylation, ubiquitination, and proteasomal breakdown of tal1 in endothelial cells. A specific serine in the putative transactivation domain of the protein, ser122, is preferentially phosphorylated by mapk in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K1 | down-regulates
phosphorylation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116149 |
Ser122 |
DGRMVQLsPPALAAP |
Homo sapiens |
|
| pmid |
sentence |
| 11904294 |
We found that hypoxia greatly accelerated tal1 turnover in these cells through mitogen-activated protein kinase (mapk)2-mediated phosphorylation, ubiquitination, and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEK1/2 | down-regulates
phosphorylation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244975 |
Ser122 |
DGRMVQLsPPALAAP |
Homo sapiens |
|
| pmid |
sentence |
| 11904294 |
We found that hypoxia greatly accelerated tal1 turnover in these cells through mitogen-activated protein kinase (mapk)2-mediated phosphorylation, ubiquitination, and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195987 |
Ser122 |
DGRMVQLsPPALAAP |
Homo sapiens |
|
| pmid |
sentence |
| 22310283 |
Thus, our data revealed a novel interplay between pka phosphorylation and tal1-mediated epigenetic regulation that regulates hematopoietic transcription and differentiation programs during hematopoiesis and leukemogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates 
phosphorylation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195983 |
Ser172 |
NRVKRRPsPYEMEIT |
Homo sapiens |
|
| pmid |
sentence |
| 22310283 |
The phosphorylation of serine 172 of tal1 specifically destabilizes tal1 interaction with histone demethylase lsd1 and, therefore, leads to the activation of the certain tal1 target genes in differentiated erythroid cells or t-cell leukemia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation
|
TAL1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252479 |
Thr90 |
EARHRVPtTELCRPP |
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 15930267 |
Akt phosphorylates tal1 oncoprotein and inhibits its repressor activity. / our results show that akt specifically phosphorylates thr90 of the tal1 protein within its transactivation domain in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates
phosphorylation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137942 |
Thr90 |
EARHRVPtTELCRPP |
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 15930267 |
Akt phosphorylates tal1 oncoprotein and inhibits its repressor activity. / our results show that akt specifically phosphorylates thr90 of the tal1 protein within its transactivation domain in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LMO1 | up-regulates
binding
|
TAL1 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46114 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 9020185 |
Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAL1 | up-regulates quantity by expression 
transcriptional regulation
|
ANGPT2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22792348 |
Here, we identified angiopoietin-2 (ang-2), which encodes a major regulator of angiogenesis, as a direct transcriptional target of tal1,lyl1and lmo2. Knockdown of any of the three transcription factors in human blood and lymphatic endothelial cells caused ang-2 mrna and protein down-regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
TAL1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256157 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
ARID5B positively regulates the expression of TAL1 and its regulatory partners. we also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STUB1 | down-regulates quantity by destabilization
ubiquitination
|
TAL1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271393 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 17962192 |
Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP. CHIP promoted Tal1 degradation with both chaperone binding and ubiquitin ligase activities, which are mediated by its TPR domain and U box, respectively. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZC3H12A | up-regulates quantity
post transcriptional regulation
|
TAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259944 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30842549 |
Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAL1 | up-regulates activity
|
Erythrocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259971 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 23319051 |
Analysis of SclΔ40/Δ40 embryonic stem (ES) cells revealed impaired erythroid differentiation, which was accompanied by a failure to upregulate Scl when erythropoiesis was initiated. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259970 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 29713515 |
The truncated form TAL1-s is required for erythroid progenitors differentiation, while the full-length protein TAL1-l is required for megakaryocytic differentiation of progenitor cells. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
TAL1 | up-regulates quantity by expression
transcriptional regulation
|
FUBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30653565 |
TAL1 directly activates the FUBP1 promoter, leading to increased FUBP1 expression during erythroid differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAL1 | up-regulates activity
|
Megakaryocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259969 |
|
|
Mus musculus |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 29713515 |
The truncated form TAL1-s is required for erythroid progenitors differentiation, while the full-length protein TAL1-l is required for megakaryocytic differentiation of progenitor cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
TAL1 | up-regulates quantity by expression
transcriptional regulation
|
ERG |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253924 |
|
|
Homo sapiens |
T-cell Acute Lymphoblastic Leukemia Cell |
| pmid |
sentence |
| 21536859 |
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA1 | up-regulates quantity by expression
transcriptional regulation
|
TAL1 |
0.776 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256047 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7632958 |
Moreover, GATA-1 but not GATA-2 or GATA-3 was able to transactivate SCL promoter 1a in a T-cell environment. These results suggest that inactivity of SCL promoter 1a in T cells reflected the absence of GATA-1 rather than the presence of trans-dominant negative regulators. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
LMO2 | up-regulates
binding
|
TAL1 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46161 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 9020185 |
Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPI1 | down-regulates activity
binding
|
TAL1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256048 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16298389 |
PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity.By expressing a mutant protein containing only the ETS domain of PU.1 in human erythroleukemic HEL cells, we demonstrated that PU.1 mediates the transcriptional repression activity of the silencer. Our data clearly demonstrate that PU.1 mediates TAL-1 silencer activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
TAL1 | down-regulates quantity by destabilization
polyubiquitination
|
TSG101 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271636 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17229889 |
These data suggest that Tal mediates polyubiquitylation of the lysine residues in the VPS28-binding region of TSG101, leading to subsequent degradation of TSG101. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAL1 | up-regulates quantity by expression
transcriptional regulation
|
UBE2H |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269000 |
|
|
|
|
| pmid |
sentence |
| 20028976 |
Tal1 expression activated UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity.|Binding of Tal1 to UBE2H was confirmed by chromatin immunoprecipitation. |
|
| Publications: |
1 |
| + |
TAL1 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254209 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
TAL1 and LYL1 are two leukemic members of the bHLH family of transcription factors. TAL1 and LYL1 activate expression of MEF2C |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TAL1
- 
- 