Summary

Name PPP1CC
Full Name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Synonyms PP-1G, Protein phosphatase 1C catalytic subunit
Primary ID P36873
Links - -
Type protein
Relations 28
Pathways COVID-19 Causal Network, SARS-CoV ER STRESS
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.325
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png dephosphorylation CDK9 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.273
Publications: 4 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT 0.394
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.394
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation AHCYL1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png dephosphorylation IFIH1 0.25
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CC 0.506
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation NOS3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP1CC 0.382
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPP1CC 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation IKZF1 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP1CC 0.461
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation EIF2S1 0.425
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates img/direct_inhibition.png dephosphorylation TGFBR1 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/direct-activation.png binding, relocalization PPP1CC 0.685
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates activity img/direct-activation.png binding PPP1CC 0.685
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS