| + |
WNT5A | up-regulates activity 
binding
|
Frizzled |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255651 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates
binding
|
ROR1 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173331 |
|
|
Homo sapiens |
Chronic Lymphocytic Leukemia Cell |
| pmid |
sentence |
| 26690702 |
Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation|Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199644 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Ror1 and ror2 bind wnt5a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22343533 |
Ror1 and ror2 bind wnt5a. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GPC4 | up-regulates
binding
|
WNT5A |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22302992 |
Gpc4 bound to wnt3a and wnt5a which activate the beta-catenin-dependent and -independent pathways, respectively, and colocalized with wnts on the cell surface. Expression of gpc4 enhanced the wnt3a-dependent beta-catenin pathway and the wnt5a-dependent beta-catenin-independent pathway, and knockdown of gpc4 suppressed both pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | down-regulates 
binding
|
FZD2 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189120 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19910923 |
Fz2 was also required for the wnt3a-dependent accumulation of beta-catenin, and wnt5a competed with wnt3a for binding to fz2 in vitro and in intact cells, thereby inhibiting the beta-catenin pathway.Wnt5a Internalized fz2 probably with ror1 or ror2 through the clathrin-mediated route, whereas wnt5a competed with wnt3a for binding to fz2 to inhibit the beta-catenin pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2808370 |
Fz2 was also required for the wnt3a-dependent accumulation of beta-catenin, and wnt5a competed with wnt3a for binding to fz2 in vitro and in intact cells, thereby inhibiting the beta-catenin pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
WNT5A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268877 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT5A | up-regulates activity 
|
MYF5 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60376 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9753670 |
Wnt4, wnt5a and wnt6 exert an intermediate effect activating both myf5 and myod equivalently in paraxial mesoderm. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates activity
binding
|
FZD3 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21903638 |
It has been shown that wnt5a activates the calcium signaling pathway in the presence of receptor fz2, 3, 4, 6 and receptor fz 5. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141434 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Endothelium |
| + |
WNT5A | up-regulates
binding
|
RYK |
0.776 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22773843 |
Purified human RYK binds to mouse Wnt1, 3a and 5a expressed in HEK293 cells. Separate experiments show that human RYK also immunopreciptitates human VANGL2 when the proteins are co-expressed in HEK293 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates
|
GSK3B |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
We demonstrate here that prototype canonical wnt3a and noncanonical wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-lrp5/6 and ror1/2, respectively-through a common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | down-regulates activity 
|
GSK3B/Axin/APC |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
We demonstrate here that prototype canonical wnt3a and noncanonical wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-lrp5/6 and ror1/2, respectively-through a common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates
binding
|
ROR2 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199647 |
|
|
Homo sapiens |
Chronic Lymphocytic Leukemia Cell |
| pmid |
sentence |
| 26690702 |
Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation|Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity
|
MYOD1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9753670 |
Wnt4, wnt5a and wnt6 exert an intermediate effect activating both myf5 and myod equivalently in paraxial mesoderm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
GLIS1 | up-regulates quantity by expression
transcriptional regulation
|
WNT5A |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269040 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32047936 |
GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIX | down-regulates quantity
transcriptional regulation
|
WNT5A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268889 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT5A | up-regulates activity
binding
|
LRP6 |
0.749 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates
binding
|
FZD5 |
0.826 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9054360 |
These results identify hfz5 as a receptor for wnt-5a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity
binding
|
FZD2 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19008118 |
Perhaps through Wnt5a acting via FZD2, might also inhibit adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | down-regulates
|
AXIN1 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
We demonstrate here that prototype canonical wnt3a and noncanonical wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-lrp5/6 and ror1/2, respectively-through a common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIB | down-regulates quantity
transcriptional regulation
|
WNT5A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268883 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GPC6 | down-regulates activity
binding
|
WNT5A |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264030 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 31756413 |
GPC6 binds to Wnt5a and inhibits its release from producing cells. Based on theseresults, and in our finding that GPC6 inhibits non-canonical Wnt signaling in the developing intestine,we tested the hypothesis that GPC6 binds to Wnt5aat the surface of the Wnt5a-producing mesenchymalcells and restrains its release from them. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity
binding
|
FZD4 |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16602827 |
We show that in addition to its inhibitory function, Wnt5a can also activate beta-catenin signaling in the presence of the appropriate Frizzled receptor, Frizzled 4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | up-regulates activity
binding
|
FZD6 |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141437 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT5A | down-regulates
|
GSK3B/Axin/APC |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
We demonstrate here that prototype canonical wnt3a and noncanonical wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-lrp5/6 and ror1/2, respectively-through a common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates activity
|
DVL1 |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
SOSTDC1 | down-regulates activity
|
WNT5A |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242736 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
WNT5A
- 
- 