Summary

Name WNT5A
Full Name Protein Wnt-5a
Synonyms WNT5A_HUMAN
Primary ID P41221
Links - -
Type protein
Relations 31
Pathways FAP: Wnt, WNT Signaling, WNT Signaling and Myogenesis
Function Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding FZD3 0.697
Publications: 3 Organism: Homo Sapiens
Tissue: Endothelium
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation WNT5A 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding FZD6 0.685
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RYK 0.775
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MYOD1 0.33
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding WNT5A 0.385
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ROR1 0.736
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD2 0.757
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GSK3B/Axin/APC 0.439
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png DVL1 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation WNT5A 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding FZD2 0.757
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AXIN1 0.494
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png GSK3B/Axin/APC 0.439
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png MYF5 0.299
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding FZD5 0.826
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding WNT5A 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ROR2 0.767
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation WNT5A 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Frizzled 0.828
Publications: 2 Organism: , Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding FZD4 0.728
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png WNT5A 0.31
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png GSK3B 0.409
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation WNT5A 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding LRP6 0.749
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis