Summary

Name MAPKAPK2
Full Name MAP kinase-activated protein kinase 2
Synonyms MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2
Primary ID P49137
Links - -
Type protein
Relations 65
Pathways FLT3-ITD signaling, P38 Signaling
Function Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SRF 0.561
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RTN4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ZFP36 0.686
Publications: 5 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.678
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.678
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ img/unknown.png phosphorylation TSC2 0.643
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KRT20 0.2
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.803
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PDE4A 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MDM2 0.372
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation RCSD1 0.496
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation UBE2J1 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TH 0.493
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ETV1 0.593
Publications: 2 Organism: Neovison Vison
+ up-regulates img/direct-activation.png phosphorylation BAG2 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZFP36L1 0.602
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LSP1 0.618
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HSPA1L 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.52
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK2 0.754
Publications: 6 Organism: Homo Sapiens, In Vitro
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.522
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LIMK1 0.367
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LPCAT2 0.2
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation EEF2K 0.359
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AGO2 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIAS1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png phosphorylation TRIM29 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PARN 0.385
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation YWHAZ 0.606
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARPC5 0.359
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HNRNPA0 0.552
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation AATF 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.487
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRF 0.561
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.493
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ETV1 0.593
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC25A 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation ELAVL1 0.311
Publications: 1 Organism: Homo Sapiens