| + |
AURKA |
phosphorylation
|
WWC1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176359 |
Ser539 |
TSLSPRSsLSSPSPP |
Homo sapiens |
|
| pmid |
sentence |
| 21878642 |
We identified the highly conserved ser(539) as the primary phosphorylation site for aurora kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKB |
phosphorylation
|
WWC1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176363 |
Ser539 |
TSLSPRSsLSSPSPP |
Homo sapiens |
|
| pmid |
sentence |
| 21878642 |
We identified the highly conserved ser(539) as the primary phosphorylation site for aurora kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 |
phosphorylation
|
WWC1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203286 |
Ser548 |
SSPSPPCsPLMADPL |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
We demonstrated that erk1/2 phosphorylate kibra at ser(548) in cells as well as in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
MAPK3 |
phosphorylation
|
WWC1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203290 |
Ser548 |
SSPSPPCsPLMADPL |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
We demonstrated that erk1/2 phosphorylate kibra at ser(548) in cells as well as in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
RPS6K | up-regulates 
phosphorylation
|
WWC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252809 |
Ser947 |
CRLNRSDsDSSTLSK |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. erk_rsk phosphorylation of kibra is required for proper cell proliferation and rsk-mediated phosphorylation also positively modulates kibra's migratory activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252810 |
Thr929 |
STIIRSKtFSPGPQS |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
WWC1 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203294 |
Ser947 |
CRLNRSDsDSSTLSK |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. erk_rsk phosphorylation of kibra is required for proper cell proliferation and rsk-mediated phosphorylation also positively modulates kibra's migratory activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203298 |
Thr929 |
STIIRSKtFSPGPQS |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
RPS6KA3 | up-regulates
phosphorylation
|
WWC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203302 |
Ser947 |
CRLNRSDsDSSTLSK |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203306 |
Thr929 |
STIIRSKtFSPGPQS |
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
PRKCZ |
phosphorylation
|
WWC1 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249262 |
Ser975 |
VRMKRPSsVKSLRSE |
in vitro |
|
| pmid |
sentence |
| 15081397 |
PKCzeta phosphorylates KIBRA at serine 975 and 978 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249263 |
Ser978 |
KRPSSVKsLRSERLI |
in vitro |
|
| pmid |
sentence |
| 15081397 |
PKCzeta phosphorylates KIBRA at serine 975 and 978 |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
WWC1 | up-regulates activity 
|
STK3 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261953 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
WWC1 | up-regulates activity
binding
|
LATS1/2 |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263659 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21233212 |
Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
ERK1/2 |
phosphorylation
|
WWC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
We demonstrated that erk1/2 phosphorylate kibra at ser(548) in cells as well as in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
WWC1 | up-regulates activity
|
STK3/4 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269951 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
WWC1 | up-regulates activity
|
STK4 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261954 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Gbeta |
phosphorylation
|
WWC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24269383 |
We demonstrated that erk1/2 phosphorylate kibra at ser(548) in cells as well as in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
WWC1 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263660 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21233212 |
We also found that KIBRA mRNA is induced by YAP overexpression in both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional target of the Hippo signaling pathway. Thus, our study revealed a new connection between KIBRA and mammalian Hippo signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
3.0
WWC1
- 
- 