Summary

Name IRF4
Full Name Interferon regulatory factor 4
Synonyms IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5 | MUM1
Primary ID Q15306
Links - -
Type protein
Relations 10
Pathways Macrophage differentiation, Macrophage: IL4, T-Lymphocyte: IL4 transcriptional regulation
Function Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL4 0.06
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation, Macrophage: IL4, T-Lymphocyte: IL4 transcriptional regulation
+ up-regulates img/direct-activation.png phosphorylation IRF4
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FCER2 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CD68 0.25
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IRF4
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation, Macrophage: IL4
+ up-regulates img/indirect-activation.png unknown M2 polarization
Publications: 2 Organism: Homo Sapiens
Pathways:Macrophage differentiation, Macrophage: IL4
+ down-regulates activity img/direct_inhibition.png unknown IRF5
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown M1 polarization
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation, Macrophage: IL4