| + |
MAPK14 | down-regulates activity 
phosphorylation
|
TAB1 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185580 |
Ser423 |
QMVNGAHsASTLDEA |
Homo sapiens |
|
| pmid |
sentence |
| 19393267 |
Egfr-mediated phosphorylation of tab1 was completely inhibited by a chemical inhibitor and sirna of p38alpha. The phosphorylation of tab1 was occurred at ser-423 and thr-431, the residues underlying the p38-mediated feedback inhibition of tak1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118922 |
Ser438 |
TPTLTNQsPTLTLQS |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 14592977 |
Tab1, a subunit of the kinase tak1, was phosphorylated by sapk2a/p38alpha at ser423, thr431 and ser438 in vitro. the results presented here also show that sapk2a/p38? Suppresses the activity of tak1 in cells, because the activation of tak1 by proinflammatory cytokines and lps is enhanced if cells are first pre?incubated With sb 203580 or in cells that do not express sapk2a/p38?. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185584 |
Thr431 |
ASTLDEAtPTLTNQS |
Homo sapiens |
|
| pmid |
sentence |
| 19393267 |
Egfr-mediated phosphorylation of tab1 was completely inhibited by a chemical inhibitor and sirna of p38alpha. The phosphorylation of tab1 was occurred at ser-423 and thr-431, the residues underlying the p38-mediated feedback inhibition of tak1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP3K7 | up-regulates activity 
phosphorylation
|
TAB1 |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276364 |
Ser452 |
STNTHTQsSSSSSDG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276366 |
Ser453 |
TNTHTQSsSSSSDGG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276365 |
Ser456 |
HTQSSSSsSDGGLFR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276367 |
Ser457 |
TQSSSSSsDGGLFRS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
TAB1 | up-regulates activity
binding
|
MAP3K7 |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17299140 |
The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. Tab1 activates the kinase activity of tak1 by directly binding to its catalytic domain. Tab1 overexpression increase the kinase activity of tak1 in mammalian cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41941 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8638164 |
The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. Tab1 activates the kinase activity of tak1 by directly binding to its catalytic domain. Tab1 overexpression increase the kinase activity of tak1 in mammalian cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
TAB1 | up-regulates
binding
|
JNK |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB1 | up-regulates activity
binding
|
MAPK14 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143576 |
|
|
Rattus norvegicus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 16407200 |
In contrast to MKK3-induced p38 kinase downstream effects, TAB-1-induced p38 kinase activation does not induce expression of pro-inflammatory genes, cardiac marker gene expression, or changes in cellular morphology. Rather, TAB-1 binds to p38 and prevents p38 nuclear localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11847341 |
Here, we report an unexpected activation mechanism for p38alpha MAPK that does not involve the prototypic kinase cascade. Rather it depends on interaction of p38alpha with TAB1 [transforming growth factor-beta-activated protein kinase 1 (TAK1)-binding protein 1] leading to autophosphorylation and activation of p38alpha. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
TAB1 | down-regulates
phosphorylation
|
ROR2 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18762249 |
Tak1 (tgf-beta activated kinase 1), a map3k, interacts with ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (stp) domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD6 | down-regulates
binding
|
TAB1 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1. The interaction of i-smads with tak1 and/or tab1 implies that several mechanisms exist underlying the repression of the tak1-p38 kinase pathway by i-smads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | up-regulates activity
binding
|
TAB1 |
0.86 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
SMAD7 | down-regulates
binding
|
TAB1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1. The interaction of i-smads with tak1 and/or tab1 implies that several mechanisms exist underlying the repression of the tak1-p38 kinase pathway by i-smads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB1 | up-regulates
binding
|
p38 |
0.821 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205440 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP14 | down-regulates activity
dephosphorylation
|
TAB1 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24403530 |
DUSP14 directly interacted with TGF-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser (438), leading to TAB1 and TAK1 complex inactivation in T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TAB1
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