| + |
MAPK3 | down-regulates 
phosphorylation
|
DUSP6 |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132975 |
Ser159 |
DGSCSSSsPPLPVLG |
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132979 |
Ser197 |
SATDSDGsPLSNSQP |
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
DUSP6 |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132967 |
Ser159 |
DGSCSSSsPPLPVLG |
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
In vitro phosphorylation assays using glutathione S-transferase (GST)-MKP-3 fusion proteins indicated that ERK2 could phosphorylate MKP-3 on serines 159 and 197Double serine mutants of MKP-3 or MKP-3-GFP were more efficiently protected from degradation than single mutants or wild-type MKP-3, indicating that phosphorylation of either serine by ERK1/2 enhances proteasomal degradation of MKP-3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132971 |
Ser197 |
SATDSDGsPLSNSQP |
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
In vitro phosphorylation assays using glutathione S-transferase (GST)-MKP-3 fusion proteins indicated that ERK2 could phosphorylate MKP-3 on serines 159 and 197Double serine mutants of MKP-3 or MKP-3-GFP were more efficiently protected from degradation than single mutants or wild-type MKP-3, indicating that phosphorylation of either serine by ERK1/2 enhances proteasomal degradation of MKP-3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | up-regulates activity 
dephosphorylation
|
FOXO1 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276983 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
|
| pmid |
sentence |
| 22848439 |
It has been previously demonstrated that MKP-3 dephosphorylates FOXO1 on Ser256 and promotes nuclear translocation of FOXO1 , which subsequentially binds to the promoters of gluconeogenic genes and turns on the gluconeogenic program.|We also reported that MKP-3 can activate FOXO1 by at least dephosphorylating Ser 256, one of the Akt phosphorylation sites xref . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | up-regulates
dephosphorylation
|
FOXO1 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates
dephosphorylation
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269905 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
DUSP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270116 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates
dephosphorylation
|
MAPK3 |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates activity
dephosphorylation
|
MAPK1 |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20638106 |
Dual-specificity phosphatase six (DUSP6, MKP3, or PYST1) dephosphorylates phosphotyrosine and phosphothreonine residues on ERK-2 (MAPK1) to inactivate the ERK-2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | up-regulates
dephosphorylation
|
FOXO |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252903 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates
dephosphorylation
|
ERK1/2 |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269926 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates
dephosphorylation
|
MAPK1 |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression 
transcriptional regulation
|
DUSP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254853 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates activity
dephosphorylation
|
MAPK8 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24861519 |
Our data demonstrate MKP-3 has differential substrate preference in astrocytes compared to other cells types, since it preferentially dephosphorylated p-JNK over p-ERK.|The main findings of our studies are (1) MKP-3 preferentially reduces p-JNK over p-ERK and p-p38 in primary astrocytes; (2) This MAPK modulation pattern in primary astrocytes significantly reduced NO and completely abolished IL-6 and TNF accumulation; and (3) These effects are specifically induced by MKP-3 since block-age of MKP-3 mRNA expression reversed its action on MAPKs and pro-inflammatory mediators in BV-2 microglia cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETV3 | down-regulates quantity by repression
transcriptional regulation
|
DUSP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262780 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 22028473 |
ETV3 target genes including etv3, ddx20, and dusp6 provide negative feedback regulation of ETV3 production and activity. Negative feedback along with constitutive instability may serve to tightly regulate ETV3 abundance. Our date suggest that phosphorylation by ERK2 relieves repression by ETV3, allowing activation of cell cycle control genes including myc, components of the NF-κB pathway, and genes required form RNA processing and translation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ERK1/2 | down-regulates
phosphorylation
|
DUSP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates activity
dephosphorylation
|
MAPK7 |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18280112 |
However, whilst the interaction itself might be difficult to monitor, DUSP6 should still be able to promote the de-phosphorylation of ERK5 in cells if it is an ERK5 phosphatase.To test this HEK293 cells were transiently transfected with HA-ERK2 or HA-ERK5 together with EGFP-MEK1E (a constitutively active version of MEK1) or EGFP-MEK5D (a constitutively active version of MEK5).|Whilst one can envisage scenarios in which the interaction between DUSPs and their substrates might be transient, DUSP6 should still be able to promote the de-phosphorylation and inactivation of ERK5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates 
|
DUSP6 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
In conclusion,insulinlikely promotes mkp-3 protein degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DUSP6
- 
- 