+ |
MAPK3 | down-regulates
phosphorylation
|
DUSP6 |
0.847 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132975 |
Ser159 |
DGSCSSSsPPLPVLG |
Homo sapiens |
|
pmid |
sentence |
15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132979 |
Ser197 |
SATDSDGsPLSNSQP |
Homo sapiens |
|
pmid |
sentence |
15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
DUSP6 |
0.901 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132967 |
Ser159 |
DGSCSSSsPPLPVLG |
Homo sapiens |
|
pmid |
sentence |
15632084 |
In vitro phosphorylation assays using glutathione S-transferase (GST)-MKP-3 fusion proteins indicated that ERK2 could phosphorylate MKP-3 on serines 159 and 197Double serine mutants of MKP-3 or MKP-3-GFP were more efficiently protected from degradation than single mutants or wild-type MKP-3, indicating that phosphorylation of either serine by ERK1/2 enhances proteasomal degradation of MKP-3. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132971 |
Ser197 |
SATDSDGsPLSNSQP |
Homo sapiens |
|
pmid |
sentence |
15632084 |
In vitro phosphorylation assays using glutathione S-transferase (GST)-MKP-3 fusion proteins indicated that ERK2 could phosphorylate MKP-3 on serines 159 and 197Double serine mutants of MKP-3 or MKP-3-GFP were more efficiently protected from degradation than single mutants or wild-type MKP-3, indicating that phosphorylation of either serine by ERK1/2 enhances proteasomal degradation of MKP-3. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
ETV3 | down-regulates quantity by repression
transcriptional regulation
|
DUSP6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262780 |
|
|
Mus musculus |
NIH-3T3 Cell |
pmid |
sentence |
22028473 |
ETV3 target genes including etv3, ddx20, and dusp6 provide negative feedback regulation of ETV3 production and activity. Negative feedback along with constitutive instability may serve to tightly regulate ETV3 abundance. Our date suggest that phosphorylation by ERK2 relieves repression by ETV3, allowing activation of cell cycle control genes including myc, components of the NF-κB pathway, and genes required form RNA processing and translation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
ERK1/2 | down-regulates
phosphorylation
|
DUSP6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270205 |
|
|
Homo sapiens |
|
pmid |
sentence |
15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | down-regulates
dephosphorylation
|
Gbeta |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269905 |
|
|
Homo sapiens |
|
pmid |
sentence |
12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | up-regulates
dephosphorylation
|
FOXO |
0.445 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252903 |
|
|
Homo sapiens |
|
pmid |
sentence |
22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | down-regulates
dephosphorylation
|
MAPK3 |
0.847 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-103149 |
|
|
Homo sapiens |
|
pmid |
sentence |
12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | down-regulates
dephosphorylation
|
MAPK1 |
0.901 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-103146 |
|
|
Homo sapiens |
|
pmid |
sentence |
12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | down-regulates
dephosphorylation
|
ERK1/2 |
0.901 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269926 |
|
|
Homo sapiens |
|
pmid |
sentence |
12840032 |
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
INS | down-regulates
|
DUSP6 |
0.396 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-197203 |
|
|
Homo sapiens |
|
pmid |
sentence |
22521266 |
In conclusion,insulinlikely promotes mkp-3 protein degradation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
F2RL1 | up-regulates quantity by expression
transcriptional regulation
|
DUSP6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254853 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
21072196 |
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP6 | up-regulates
dephosphorylation
|
FOXO1 |
0.445 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-197194 |
|
|
Homo sapiens |
|
pmid |
sentence |
22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Gbeta | down-regulates
phosphorylation
|
DUSP6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270116 |
|
|
Homo sapiens |
|
pmid |
sentence |
15632084 |
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |