Summary

Name DYRK1B
Full Name Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Synonyms Minibrain-related kinase, Mirk protein kinase | MIRK
Primary ID Q9Y463
Links - -
Type protein
Relations 15
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.367
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1A 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HDAC9 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation HNF1A 0.521
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC5 0.38
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation GYS1 0.261
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.427
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation DYRK1B 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Myotube
+ down-regulates activity img/direct_inhibition.png binding DYRK1B 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MEF2C 0.288
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation DYRK1B 0.355
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding DYRK1B 0.757
Publications: 1 Organism: Chlorocebus Aethiops