4.0
Fructose metabolism
Pathway ID: SIGNOR-FX
Description: Fructose catabolism mainly takes place in the liver. Fructose is first phosphorylated by fructokinase to form fructose-1-phosphate, bypassing the main regulatory step of glycolysis. Fructose-1-phosphate is then split by aldolase B into dihydroxyacetone phosphate (DHAP) and glyceraldehyde. DHAP can enter glycolysis or gluconeogenesis directly, while glyceraldehyde is converted by triose kinase into glyceraldehyde-3-phosphate, another glycolysis intermediate. In this way, fructose enters the main metabolic pathways, providing triose phosphates that can be used to make ATP, glucose, or fats depending on the body’s needs.
Curated by: Marta Iannuccelli
Use SIGNOR Cytoscape App
Description: Fructose catabolism mainly takes place in the liver. Fructose is first phosphorylated by fructokinase to form fructose-1-phosphate, bypassing the main regulatory step of glycolysis. Fructose-1-phosphate is then split by aldolase B into dihydroxyacetone phosphate (DHAP) and glyceraldehyde. DHAP can enter glycolysis or gluconeogenesis directly, while glyceraldehyde is converted by triose kinase into glyceraldehyde-3-phosphate, another glycolysis intermediate. In this way, fructose enters the main metabolic pathways, providing triose phosphates that can be used to make ATP, glucose, or fats depending on the body’s needs.
Curated by: Marta Iannuccelli
Use SIGNOR Cytoscape App
15 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| D-glyceraldehyde 3-phosphate(2-) | CHEBI:59776 |
| STUB1 | Q9UNE7 |
| Food intake | SIGNOR-PH152 |
| MAPK3 | P27361 |
| KHK | P50053 |
| Glycolysis | SIGNOR-PH34 |
| ALDOB | P05062 |
| D-glycerate | CHEBI:16659 |
| ALDH1A1 | P00352 |
| D-glyceraldehyde | CHEBI:17378 |
| GLYCTK | Q8IVS8 |
| 3-phosphonato-D-glycerate(3-) | CHEBI:58272 |
| beta-D-fructofuranose | CHEBI:28645 |
| glycerone phosphate(2-) | CHEBI:57642 |
| beta-D-fructofuranose 1-phosphate(2-) | CHEBI:138881 |