| + |
DBP | up-regulates quantity by expression 
transcriptional regulation
|
ALDOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253833 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDOB | up-regulates quantity 
chemical modification
|
glycerone phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280244 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10970798 |
Fructoaldolases (EC 4.1.2.13) catalyse the specific and reversible cleavage of fructose 1,6-bisphosphate (FBP) and fructose 1-phosphate (F1P) into dihydroxyacetone phosphate and -glyceraldehyde 3-phosphate or -glyceraldehyde respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255061 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255055 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDOB | down-regulates quantity 
chemical modification
|
beta-D-fructofuranose 1,6-bisphosphate(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
ALDOB | down-regulates quantity
chemical modification
|
beta-D-fructofuranose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280241 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10970798 |
Fructoaldolases (EC 4.1.2.13) catalyse the specific and reversible cleavage of fructose 1,6-bisphosphate (FBP) and fructose 1-phosphate (F1P) into dihydroxyacetone phosphate and -glyceraldehyde 3-phosphate or -glyceraldehyde respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDOB | up-regulates quantity
chemical modification
|
D-glyceraldehyde |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280245 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10970798 |
Fructoaldolases (EC 4.1.2.13) catalyse the specific and reversible cleavage of fructose 1,6-bisphosphate (FBP) and fructose 1-phosphate (F1P) into dihydroxyacetone phosphate and -glyceraldehyde 3-phosphate or -glyceraldehyde respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDOB | up-regulates quantity
chemical modification
|
D-glyceraldehyde 3-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
4.0
ALDOB
- 
- 