Myofiber: Calcium-mediated fusion

Pathway ID: SIGNOR-MCMF

Description: Myoblast fusion is strictly dependent on calcium signaling. The intracellular increase of calcium leads to the activation of the Ser/Thr phosphatase calcineurin which dephosphorylates NFATc2, enabling its nuclear import. In the nucleus, NFATc2 promotes myoblast fusion by regulating IL4 and myoferlin production.

Curated by: Alessio Reggio

8 Seed Entities

Organism:
Name Primary ID
NFATC2 Q13469
IL4 P05112
MYOF Q9NZM1
MEF2A Q02078
Myoblast_fusion SIGNOR-PH98
CAMK2D Q13557
calcium(2+) CHEBI:29108
Calcineurin SIGNOR-C155