3.0
Myofiber: Calcium-mediated fusion
| Type: | Score: | Layout: | SPV |
Pathway ID: SIGNOR-MCMF
Description: Myoblast fusion is strictly dependent on calcium signaling. The intracellular increase of calcium leads to the activation of the Ser/Thr phosphatase calcineurin which dephosphorylates NFATc2, enabling its nuclear import. In the nucleus, NFATc2 promotes myoblast fusion by regulating IL4 and myoferlin production.
Curated by: Alessio Reggio
Description: Myoblast fusion is strictly dependent on calcium signaling. The intracellular increase of calcium leads to the activation of the Ser/Thr phosphatase calcineurin which dephosphorylates NFATc2, enabling its nuclear import. In the nucleus, NFATc2 promotes myoblast fusion by regulating IL4 and myoferlin production.
Curated by: Alessio Reggio
8 Seed Entities
Organism: 
|
|
| Name | Primary ID |
|---|---|
| NFATC2 | Q13469 |
| IL4 | P05112 |
| MYOF | Q9NZM1 |
| MEF2A | Q02078 |
| Myoblast_fusion | SIGNOR-PH98 |
| CAMK2D | Q13557 |
| calcium(2+) | CHEBI:29108 |
| Calcineurin | SIGNOR-C155 |