T-Lymphocyte: IL10

Pathway ID: SIGNOR-TLymphIL10

Description: IL-10 is a potent anti-inflammatory cytokine. It binds its receptor (IL10R1) activating JAK/STAT3 signaling pathway. STAT3 can activate ROR gamma-t and inhibit FOXP3, which is a master gene for T regulatory cells. TBET transcription factor promotes Th1 differentiation and inhibits IL-10 gene transcription, while FOXP3 has been identified as a promoter of IL-10 transcription

Curated by: Alessandro Palma

8 Seed Entities

Organism:
Name Primary ID
IL10 P22301
IL10RA Q13651
FOXP3 Q9BZS1
RORC P51449
TBX21 Q9UL17
JAK1 P23458
JAK2 O60674
STAT3 P40763