3.0
Summary
| Name |  IL10RAView Modifications |
| Full Name | Interleukin-10 receptor subunit alpha |
| Synonyms | IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1 | IL10R |
| Primary ID | Q13651 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | iCAF signaling in PDAC, Macrophage polarization, Macrophage: IL10, Macrophage: Polarization and myogenesis, Multiple sclerosis, SARS-CoV CYTOKINE STORM, T-Lymphocyte: IL10 |
| Function | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | JAK1 | up-regulates activity 
phosphorylation
|
IL10RA | 0.801 |
| Publications: | 2 | |||
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM | |||
| + | IL10 | up-regulates
binding
|
IL10RA | 0.911 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM | |||
| + | IL10RA | up-regulates activity
phosphorylation
|
JAK2 | 0.42 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IL10RA | up-regulates 
|
Phagocytosis | 0.7 |
| Publications: | 2 | |||
| + | IL10RA | up-regulates activity
, binding
|
JAK1 | 0.801 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM | |||
| + | IL10 | up-regulates activity
binding
|
IL10RA | 0.911 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM | |||