| + |
phosphatidic acid | up-regulates quantity 
precursor of
|
long-chain fatty acid anion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22922100 |
Members of the intracellular phospholipase A1 family of proteins have been implicated in organelle biogenesis and membrane trafficking. The mammalian family comprises three members: phosphatidic acid-preferring phospholipase A1 (PA-PIA1)/DDHD1, p125/Sec23ip and KIAA0725p/DDHD2, all of which have a DDHD domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-acyl-sn-glycerol 3-phosphate(2-) | up-regulates quantity
precursor of
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21173190 |
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA).  |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267013 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21173190 |
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA).  |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267010 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21173190 |
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA).  |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
MAPK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164289 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20231899 |
In addition, extracellular signal-regulated kinase (erk) is stimulated by ampk-induced pld1 activation through the formation of phosphatidic acid (pa), which is a product of pld |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
CDS2 | down-regulates quantity 
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267021 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25375833 |
CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDS1 | down-regulates quantity
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267018 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25375833 |
CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGPAT3 | up-regulates
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12401205 |
Pa can be generated by the acylation of lyso-pa by lyso-pa acyl transferases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEC23IP | down-regulates quantity
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22922100 |
Members of the intracellular phospholipase A1 family of proteins have been implicated in organelle biogenesis and membrane trafficking. The mammalian family comprises three members: phosphatidic acid-preferring phospholipase A1 (PA-PIA1)/DDHD1, p125/Sec23ip and KIAA0725p/DDHD2, all of which have a DDHD domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
SOS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17486115 |
Phosphatidic acid interacts with a defined site in the sos ph domain with high affinity and specificity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
PIP5K1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17245604 |
All pip5k isoforms are stimulated by pa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDHD1 | down-regulates quantity
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22922100 |
Members of the intracellular phospholipase A1 family of proteins have been implicated in organelle biogenesis and membrane trafficking. The mammalian family comprises three members: phosphatidic acid-preferring phospholipase A1 (PA-PIA1)/DDHD1, p125/Sec23ip and KIAA0725p/DDHD2, all of which have a DDHD domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates quantity
precursor of
|
CDP-diacylglycerol(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25375833 |
CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267022 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25375833 |
CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLD1 | up-regulates
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9873061 |
The primary known function of phospholipase d (pld) is to generate phosphatidic acid (pa) via the hydrolysis of phosphatidylcholine. . phospholipase d (pld) hydrolyzes phospholipids to generate phosphatidic acid (pa). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
MTOR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11729323 |
Pa directly interacted with the domain in mtor that is targeted by rapamycin, and this interaction was positively correlated with mtor's ability to activate downstream effectors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
PRKCZ |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12401205 |
The pkc isoform pkc-zeta appear to be activated by direct interactions with pa |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGPAT4 | up-regulates
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267014 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21173190 |
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
RAC1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18480413 |
The c-terminal polybasic motif of rac1 is responsible for direct interaction with pa, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGPAT5 | up-regulates
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267011 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21173190 |
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDHD2 | down-regulates quantity
chemical modification
|
phosphatidic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269649 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22922100 |
Members of the intracellular phospholipase A1 family of proteins have been implicated in organelle biogenesis and membrane trafficking. The mammalian family comprises three members: phosphatidic acid-preferring phospholipase A1 (PA-PIA1)/DDHD1, p125/Sec23ip and KIAA0725p/DDHD2, all of which have a DDHD domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
phosphatidic acid