| + |
GDP | down-regulates activity 
chemical inhibition
|
PRPS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265738 |
|
|
|
|
| pmid |
sentence |
| 29074724 |
PRPS1 is inhibited by the nucleotide biosynthesis products ADP, AMP, and GDP |
|
| Publications: |
1 |
| + |
GDP | down-regulates
chemical inhibition
|
GNAI1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88226 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12040175 |
Galfa subunits cycle between inactive (gdp-bound) and active (gtp-bound) states, and the lifetime of the active state is limited by gtp hydrolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADSS1 | up-regulates quantity 
chemical modification
|
GDP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10496970 |
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ADSS2 | up-regulates quantity
chemical modification
|
GDP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10496970 |
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
GDP | down-regulates
chemical inhibition
|
GNAQ |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12040175 |
Agonist binding triggers a conformational change in the receptor, which catalyses the dissociation of gdp from the alfa subunit followed by gtp-binding to galfa and the dissociation of galfa from gbetagamma subunits1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDP | down-regulates
chemical inhibition
|
GNAS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253072 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17095603 |
Galfa subunits cycle between inactive (GDP-bound) and active (GTP-bound) states, and the lifetime of the active state is limited by GTP hydrolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDP | down-regulates
chemical inhibition
|
GNAS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17095603 |
Galfa subunits cycle between inactive (gdp-bound) and active (gtp-bound) states, and the lifetime of the active state is limited by gtp hydrolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IMP | up-regulates quantity
precursor of
|
GDP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268130 |
|
|
|
|
| pmid |
sentence |
| 10496970 |
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP. |
|
| Publications: |
1 |
| Pathways: | Nucleotide Biosynthesis |
3.0
GDP