| + |
sphingosine 1-phosphate | down-regulates 
|
LATS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198550 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | down-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269864 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | up-regulates 
chemical activation
|
S1PR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16794003 |
The evidence suggests that s1p acting on s1p receptors coupled to gq. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23450633 |
S1p action on yap in 293a (or hacat) cells is mediated by s1p2 rather than s1p1 or s1p3 (of ? Ve known s1p receptors) and lpa receptors 1 and 3 (of six). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | up-regulates
chemical activation
|
S1PR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16794003 |
The evidence suggests that s1p acting on s1p receptors coupled to gq |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCC4 | up-regulates quantity
relocalization
|
sphingosine 1-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265912 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29304533 |
Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | up-regulates activity
chemical activation
|
S1PR3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261142 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10617617 |
We observed that S1P treatment significantly increased proliferation of HTC4 hepatoma cells stably transfected with human S1P receptor Edg3 or Edg5, which was attributable to stimulation of cell growth and inhibition of apoptosis caused by serum starvation. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
sphingosine 1-phosphate | up-regulates activity
chemical activation
|
S1PR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261141 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10617617 |
We observed that S1P treatment significantly increased proliferation of HTC4 hepatoma cells stably transfected with human S1P receptor Edg3 or Edg5, which was attributable to stimulation of cell growth and inhibition of apoptosis caused by serum starvation. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
sphingosine 1-phosphate | up-regulates activity
chemical activation
|
S1PR4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261143 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10753843 |
These results indicate that EDG-6 is a high affinity receptor for SPP, which couples to a G(i/o) protein, resulting in the activation of growth-related signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | down-regulates
|
LATS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198553 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | up-regulates
chemical activation
|
S1PR3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16794003 |
The evidence suggests that s1p acting on s1p receptors coupled to gq |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
sphingosine 1-phosphate