+ |
XAV939 | down-regulates
chemical inhibition
|
TNKS |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-188054 |
|
|
Homo sapiens |
|
pmid |
sentence |
19759537 |
Xav939 inhibits the poly-adp-ribosylating enzymes tankyrase 1 and tankyrase 2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-207830 |
|
|
Homo sapiens |
|
pmid |
sentence |
Other |
|
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
XAV939 | down-regulates
chemical inhibition
|
TNKS2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-207833 |
|
|
Homo sapiens |
|
pmid |
sentence |
Other |
|
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-188057 |
|
|
Homo sapiens |
|
pmid |
sentence |
19759537 |
Xav939 inhibits the poly-adp-ribosylating enzymes tankyrase 1 and tankyrase 2. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
XAV939 | down-regulates activity
chemical inhibition
|
TNKS |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259994 |
|
|
in vitro |
|
pmid |
sentence |
19759537 |
In biochemical activity assays, XAV939 strongly inhibited TNKS1 and TNKS2, with half-maximal inhibitory concentration values of 0.011 and 0.004 μM, respectively, but displayed much weaker effects on PARP1 and PARP2 |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
XAV939 | up-regulates
|
AXIN1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-188045 |
|
|
Homo sapiens |
|
pmid |
sentence |
19759537 |
Using a quantitative chemical proteomic approach, we discovered that xav939 stabilizes axin by inhibiting the poly-adp-ribosylating enzymes tankyrase 1 and tankyrase 2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
XAV939 | down-regulates
|
CTNNB1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-188051 |
|
|
Homo sapiens |
|
pmid |
sentence |
19759537 |
Xav939 selectively inhibits beta-catenin-mediated transcription. Xav939 stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
XAV939 | down-regulates activity
chemical inhibition
|
TNKS2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259995 |
|
|
in vitro |
|
pmid |
sentence |
20565110 |
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
XAV939 | up-regulates
|
AXIN2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-188048 |
|
|
Homo sapiens |
|
pmid |
sentence |
19759537 |
Using a quantitative chemical proteomic approach, we discovered that xav939 stabilizes axin by inhibiting the poly-adp-ribosylating enzymes tankyrase 1 and tankyrase 2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |