| + |
AXIN2 | up-regulates 
binding
|
APC |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
| + |
RNF146 | down-regulates quantity by destabilization 
ubiquitination
|
AXIN2 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263336 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21478859 |
Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated proteins. Using proteomics approaches, we have identified BLZF1 and CASC3 as further substrates targeted by tankyrase and RNF146 for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN2 | down-regulates 
|
CTNNB1 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11940574 |
Although wnts act to stabilize _-catenin levels in the cytosol and nucleus, a multiprotein complex containing adenomatous polyposis coli, glycogen synthase kinase 3_, and axin1 or its homolog axin2/axil/conductin promotes _-catenin phosphorylation and subsequent proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
RNF146 | down-regulates quantity
ubiquitination
|
AXIN2 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259997 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21799911 |
By RNAi screening, we identified the RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FHIT | down-regulates quantity by repression
transcriptional regulation
|
AXIN2 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18077326 |
In binding to the beta-catenin c-terminal domain, fhit represses transcription of target genes such as cyclin d1, axin2, mmp-14, and survivin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNKS | down-regulates quantity by destabilization
ADP-ribosylation, ubiquitination
|
AXIN2 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263381 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19759537 |
Together, these findings are consistent with the hypothesis that TNKS promotes the ubiquitination and degradation of axin, which may be mediated, at least in part, through the direct PARsylation of axin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187975 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19759537 |
Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TNKS2 | down-regulates quantity by destabilization
ADP-ribosylation
|
AXIN2 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263380 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19759537 |
Together, these findings are consistent with the hypothesis that TNKS promotes the ubiquitination and degradation of axin, which may be mediated, at least in part, through the direct PARsylation of axin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XAV939 | up-regulates 
|
AXIN2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19759537 |
Using a quantitative chemical proteomic approach, we discovered that xav939 stabilizes axin by inhibiting the poly-adp-ribosylating enzymes tankyrase 1 and tankyrase 2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN2 | down-regulates
binding
|
CTNNB1 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79947 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
| + |
AXIN2 | up-regulates activity
binding
|
GSK3B |
0.822 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
| + |
TNKS2 | down-regulates
ubiquitination
|
AXIN2 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19759537 |
Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN2 | up-regulates activity
binding
|
GSK3B/Axin/APC |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
3.0
AXIN2
- 
- 