Summary

Name AXIN2
Full Name Axin-2
Synonyms Axin-like protein, Axil, Axis inhibition protein 2, Conductin
Primary ID Q9Y2T1
Links - -
Type protein
Relations 9
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ down-regulates img/indirect_inhibition.png CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AXIN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding APC 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ up-regulates img/indirect-activation.png AXIN2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AXIN2 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination AXIN2 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ up-regulates activity img/direct-activation.png binding GSK3B 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung