Summary

Name MEN1
Full Name Menin
Synonyms MEN1_HUMAN | SCG2
Primary ID O00255
Links - -
Type protein
Relations 13
Pathways Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding MLL-ENL 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding KMT2A 0.716
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MLL-AF4 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding MLL-AF9 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ down-regulates img/direct_inhibition.png binding RELA 0.478
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png binding FANCD2 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NfKb-p65/p50 0.435
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/direct-activation.png methylation HOXA9 0.494
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2C 0.506
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MLL Fusion 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ down-regulates img/indirect_inhibition.png TERT 0.314
Publications: 1 Organism: Homo Sapiens