3.0
Summary
| Name |  WASLView Modifications |
| Full Name | Neural Wiskott-Aldrich syndrome protein |
| Synonyms | N-WASP |
| Primary ID | O00401 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ABL1 | up-regulates activity 
phosphorylation
|
WASL | 0.566 |
| Publications: | 2 | Organism: | In Vitro | |
| + | ABL1 |
phosphorylation
|
WASL | 0.566 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PTPN2 | down-regulates 
dephosphorylation
|
WASL | 0.293 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WIPF1 | up-regulates activity
binding
|
WASL | 0.931 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | phosphatidylinositol bisphosphate | up-regulates activity
chemical activation
|
WASL | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WASL | up-regulates activity
binding
|
ARP2/3 | 0.781 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEB | up-regulates
binding
|
WASL | 0.36 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCK1 | up-regulates
binding
|
WASL | 0.772 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC42 | up-regulates activity
binding
|
WASL | 0.917 |
| Publications: | 1 | Organism: | Homo Sapiens | |