Summary

Name WASL
Full Name Neural Wiskott-Aldrich syndrome protein
Synonyms N-WASP
Primary ID O00401
Links - -
Type protein
Relations 10
Function Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation WASL 0.57
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation WASL 0.57
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation WASL 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding WASL 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding WASL 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding WASL 0.917
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARP2/3 0.78
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding WASL 0.931
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation WASL 0.8
Publications: 1 Organism: Homo Sapiens