4.0
Summary
| Name |  NCK1View Modifications |
| Full Name | Cytoplasmic protein NCK1 |
| Synonyms | NCK adaptor protein 1, Nck-1, SH2/SH3 adaptor protein NCK-alpha | NCK |
| Primary ID | P16333 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Pathways | EGFR Signaling, Mitochondrial dynamics in T cell exhaustion, T cell activation |
| Function | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ABL1 | up-regulates 
phosphorylation
|
NCK1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | up-regulates activity
binding
|
NCK1 | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EGFR Signaling | |||
| + | NCK1 | up-regulates
binding
|
PAK1 | 0.71 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops, Homo Sapiens | |
| Pathways: | EGFR Signaling, T cell activation | |||
| + | CBL | down-regulates quantity by destabilization 
ubiquitination
|
NCK1 | 0.645 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCK1 | up-regulates activity
binding
|
PAK1 | 0.71 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | EGFR Signaling, T cell activation | |||
| + | CD3 | up-regulates activity
relocalization
|
NCK1 | 0.337 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | T cell activation | |||
| + | EGFR | up-regulates activity
binding
|
NCK1 | 0.573 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | EGFR Signaling | |||
| + | PDGFRB | up-regulates
binding
|
NCK1 | 0.638 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CD3E | up-regulates activity
relocalization
|
NCK1 | 0.37 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | T cell activation | |||
| + | EGFR | up-regulates 
|
NCK1 | 0.573 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EGFR Signaling | |||
| + | NCK1 | up-regulates
binding
|
SOS1 | 0.616 |
| Publications: | 1 | Organism: | Cricetulus Griseus | |
| Pathways: | EGFR Signaling, T cell activation | |||
| + | EIF2AK2 | down-regulates activity
phosphorylation
|
NCK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCK1 | up-regulates
binding
|
WASL | 0.782 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCKIPSD |
binding
|
NCK1 | 0.668 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCK1 | down-regulates activity
binding
|
ABL1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |