+ |
STK25 | up-regulates
phosphorylation
|
CCM2 |
0.501 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263144 |
Ser384 |
GRGIITDsFGRHRRA |
Homo sapiens |
Medulloblastoma Cell |
pmid |
sentence |
22782892 |
CCM2 can be phosphorylated by STK25, and the kinase activity of STK25 is required for death signaling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK25 |
phosphorylation
|
PDCD10 |
0.767 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-185388 |
Ser39 |
ELERVNLsAAQTLRA |
Homo sapiens |
|
pmid |
sentence |
19370760 |
Stk25 phosphorylates ccm3 at serine 39 and threonine 43 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-185392 |
Thr43 |
VNLSAAQtLRAAFIK |
Homo sapiens |
|
pmid |
sentence |
19370760 |
Stk25 phosphorylates ccm3 at serine 39 and threonine 43 |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
STK25 | down-regulates activity
phosphorylation
|
SAV1 |
0.28 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278369 |
Thr26 |
GKYVKKEtSPLLRNL |
Homo sapiens |
|
pmid |
sentence |
32292165 |
STK25 inhibits the ability of SAV1 to counteract STRIPAK.|Using this antibody, we confirmed that SAV1 WT was indeed phosphorylated by STK25 at T26 in human cells (XREF_FIG). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PTPN13 | down-regulates activity
dephosphorylation
|
STK25 |
0.421 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248711 |
|
|
Homo sapiens |
|
pmid |
sentence |
17657516 |
To investigate dephosphorylation of CCM3 by FAP-1, phosphorylated GST-CCM3 was incubated with cdFAP-1, and reactions were analyzed by autoradiography. Again, GST-STK25 phosphorylated GST-CCM3 and possessed autophosphorylation activity. cdFAP-1 of 0.005 U were sufficient to dephosphorylate GST-CCM3 as well as the kinase GST-STK25.|More recently, the Golgi matrix protein GM130 was shown to function as a scaffold protein for STK25 and to activate STK25 through stimulation of autophosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK25 | up-regulates activity
phosphorylation
|
LAT |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279294 |
|
|
Homo sapiens |
|
pmid |
sentence |
30948712 |
In sum, these data reveal that STK25 activates LATS kinases through a mechanism that is distinct from what has been characterized for the MAP4K/MST kinases (Fig.\u00a0 xref ).|Mechanistically, we demonstrate that STK25 promotes LATS phosphorylation at the activation loop in the absence of hydrophobic motif phosphorylation, which distinguishes it from all of the other known LATS-activating kinases discovered to date. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK25 | up-regulates activity
phosphorylation
|
YAP1 |
0.264 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278993 |
|
|
Homo sapiens |
|
pmid |
sentence |
30948712 |
Collectively, our data demonstrate that loss of STK25 promotes YAP/TAZ activation.|Lastly, we assessed if STK25 is able to promote YAP phosphorylation in the absence of LATS-HM phosphorylation, based on our in vitro kinase assay results. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |