Summary

Name TNFRSF10B
Full Name Tumor necrosis factor receptor superfamily member 10B
Synonyms Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2 | DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Primary ID O14763
Links - -
Type protein
Relations 7
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFRSF10B 0.636
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TNFRSF10B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TNFRSF10B 0.931
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TNFRSF10B 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FADD 0.844
Publications: 1 Organism: Homo Sapiens