Name	TNFRSF10B
Full Name	Tumor necrosis factor receptor superfamily member 10B
Synonyms	Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2 \| DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Primary ID	O14763
Links	- -
Type	protein
Relations	7
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.