3.0
Summary
| Name |  KDM6BView Modifications |
| Full Name | Lysine-specific demethylase 6B |
| Synonyms | JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Lysine demethylase 6B | JMJD3, KIAA0346 |
| Primary ID | O15054 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | Macrophage polarization, Macrophage: IL4 |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KDM6B | down-regulates activity 
demethylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF1A | up-regulates quantity by expression 
transcriptional regulation
|
KDM6B | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM6B | up-regulates 
|
M2_polarization | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | EPAS1 | up-regulates quantity by expression
transcriptional regulation
|
KDM6B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
KDM6B | 0.8 |
| Publications: | 1 | |||
| + | KDM6B | down-regulates activity
demethylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM6B | up-regulates quantity by expression
transcriptional regulation
|
IRF4 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | KDM6B | down-regulates 
|
M1_polarization | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | STAT6 | up-regulates quantity by expression
transcriptional regulation
|
KDM6B | 0.445 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||