Macrophage polarization

Pathway ID: SIGNOR-M1M2View in NDEx

Description: Macrophages constitute a very heterogeneous population of phagocytic cells, involved in immune-related and non-immune related processes and therefore, depending upon their immediate environment, can have very distinct phenotypes. One of the most popular classification divides activated macrophages into 2 categories: M1, known as “pro-inflammatory” and M2, known as “anti-inflammatory” macrophages. M1s are induced by IFNg, microbial stimuli (such as PAMPs), or cytokines, while M2s are induced by IL4, Il10 and IL13.

Curated by: Alessandro Palma

26 Seed Entities

Organism:
Name Primary ID
STAT6 P42226
IL10 P22301
IL10RA Q13651
M1_polarization SIGNOR-PH54
IL4 P05112
IL4R P24394
MAP3K1 Q13233
TICAM1 Q8IUC6
IL13 P35225
STAT3 P40763
IRF4 Q15306
PAMPs SIGNOR-ST11
IFNGR2/INFGR1 SIGNOR-C142
PPARG P37231
RIPK1 Q13546
M2_polarization SIGNOR-PH55
IFNG P01579
IKK-complex SIGNOR-C14
JAK2 O60674
SOCS1 O15524
NfKb-p65/p50 SIGNOR-C13
TLR4 O00206
MAP2K4 P45985
MAPK8 P45983
TICAM2 Q86XR7
KDM6B O15054