Summary

Name PER1
Full Name Period circadian protein homolog 1
Synonyms hPER1, Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui | KIAA0482, PER, RIGUI
Primary ID O15534
Links - -
Type protein
Relations 17
Pathways Circadian clock
Function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER1 0.807
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding CLOCK/BMAL1 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER1 0.716
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PER1 0.347
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png relocalization PER1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.732
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.733
Publications: 1
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding BMAL1/NPAS2 0.716
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER1 0.269
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates img/direct_inhibition.png ubiquitination PER1 0.568
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PER1 0.842
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER1 0.842
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ down-regulates img/direct_inhibition.png ubiquitination PER1 0.492
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PER1 0.395
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SLC5A1 0.337
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.73
Publications: 1
Pathways:Circadian clock