| + |
NFIL3 | up-regulates 
|
Survival |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242760 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 10082541 |
the effect of NFIL3 on cytokine-mediated cell survival was independent of an effect on cell proliferation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | down-regulates 
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256653 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 10082541 |
NFIL3 inhibits apoptosis without affecting Bcl-xL expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | up-regulates quantity by expression 
transcriptional regulation
|
IL3 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266222 |
|
|
Hylobates lar |
|
| pmid |
sentence |
| 7565758 |
NF-IL3A transactivates the IL-3 promoter through the A region sequences. |
|
| Publications: |
1 |
Organism: |
Hylobates Lar |
| + |
PTEN | up-regulates quantity by expression
transcriptional regulation
|
NFIL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260055 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11494141 |
Defects in PTEN, a tumor suppressor, have been found in cancers arising in a variety of human tissues. To elucidate the tumor-suppressive function of this gene, we have been analysing expression profiles of cancer cells after introduction of exogenous PTEN. Those experiments identified 99 candidate genes that were transcriptionally transactivated. Among them, we report here the further analyses of eight genes, EGR2/Krox-20, BPOZ, APS, HCLS1/HS1, DUSP1/MKP1, NDRG1/Drg1/RTP, NFIL3/E4BP4, and a novel gene (PINK1, PTEN-induced putative kinase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KRAS | up-regulates
|
NFIL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242757 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 10082541 |
A constitutively active Ras protein [Ras(G12V)] regulates the stable expression of the NFIL3 transcription factor through both the Raf-MAPK and PI3-K pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | down-regulates quantity by repression
transcriptional regulation
|
CYP3A4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253836 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18004209 |
The oscillation in the expression of the CYP3A4 gene seemed to be the underlying cause of the rhythmic change in its metabolic activity. Luciferase reporter gene analysis and electrophoretic mobility shift assay revealed that the circadian transcriptional factor, D-site-binding protein (DBP), activated the transcription of the CYP3A4 gene by binding to the DNA sequence near the upstream of the transcriptional start site. The transactivation of the CYP3A4 gene by DBP was repressed by the E4 promoter-binding protein-4 (E4BP4), a negative component of the circadian clock. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIL3 | down-regulates quantity by repression
transcriptional regulation
|
SOSTDC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242767 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 25338303 |
E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
NFIL3 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19805059 |
GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and regulates target gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
IL3 | up-regulates
|
NFIL3 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242763 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10082541 |
We previously reported that NFIL3 is an IL-3-responsive gene in Baf-3 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | up-regulates activity
binding
|
NFIL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224248 |
|
|
in vitro |
|
| pmid |
sentence |
| 12805554 |
E4BP4, ATF-6, OASIS, and XBP-1 all formed strong homodimeric associations on the array Transcription factor dimerization can increase the selectivity of protein-DNA interactions and generate a large amount of DNA binding diversity from a relatively small number of proteins |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Circadian clock |
| + |
NFIL3 | down-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256618 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 10082541 |
NFIL3 inhibits apoptosis without affecting Bcl-xL expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | down-regulates quantity by repression 
transcriptional regulation
|
PER1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11316793 |
E4BP4, a basic leucine zipper transcription factor, contains a DNA-binding domain closely related to DBP, HLF, and TEF, which are PAR proteins. Here, we show that the phase of e4bp4 mRNA rhythm is opposite to that of the dbp, hlf, and tef rhythms in the suprachiasmatic nucleus (SCN), the mammalian circadian center, and the liver. The protein levels of E4BP4 and DBP also fluctuate in almost the opposite phase. All PAR proteins activate, whereas E4BP4 suppresses the mPer1 promoter through the same sequence |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
3.0
NFIL3
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