3.0
Summary
| Name |  SPRY2View Modifications |
| Full Name | Protein sprouty homolog 2 |
| Synonyms | Spry-2 |
| Primary ID | O43597 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MKNK1 | down-regulates 
phosphorylation
|
SPRY2 | 0.503 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | DYRK1A | down-regulates
phosphorylation
|
SPRY2 | 0.313 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | up-regulates 
phosphorylation
|
SPRY2 | 0.546 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPRY2 | down-regulates 
|
CBLC | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPRY2 | up-regulates 
|
PTPN1 | 0.42 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEDD4 | down-regulates quantity by destabilization
polyubiquitination
|
SPRY2 | 0.398 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPRY2 | down-regulates
binding
|
CBLB | 0.497 |
| Publications: | 1 | Organism: | Homo Sapiens | |