4.0
Summary
| Name |  CBLBView Modifications |
| Full Name | E3 ubiquitin-protein ligase CBL-B |
| Synonyms | Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B | RNF56 |
| Primary ID | Q13191 |
| Links |  -  -  |
| Type | protein |
| Relations | 20 |
| Pathways | Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CBLB | down-regulates quantity 
ubiquitination
|
STAT6 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TYRO3 | up-regulates activity 
phosphorylation
|
CBLB | 0.35 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SPRY2 | down-regulates
binding
|
CBLB | 0.483 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | up-regulates activity 
|
TP53 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, KIT in AML | |||
| + | CBLB | up-regulates activity
binding
|
NCK1 | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EGFR Signaling | |||
| + | Ub:E2 | up-regulates activity
ubiquitination
|
CBLB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates quantity by destabilization
ubiquitination
|
IGF1R | 0.422 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates quantity by destabilization
polyubiquitination
|
PIK3R1 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates activity
ubiquitination
|
EGFR | 0.759 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling | |||
| + | CBLB | down-regulates quantity by destabilization
polyubiquitination
|
EGFR | 0.759 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling | |||
| + | CBLB | down-regulates activity
ubiquitination
|
FLT3 | 0.324 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | CBLB | up-regulates activity
binding
|
GRB2 | 0.565 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling | |||
| + | CBLB | down-regulates quantity
ubiquitination
|
NTRK1 | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates quantity by destabilization
ubiquitination
|
CLEC6A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | up-regulates activity
ubiquitination
|
TYRO3 | 0.35 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates activity
ubiquitination
|
KIT | 0.326 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, KIT in AML | |||
| + | CBLB | down-regulates activity
ubiquitination
|
PIK3R2 | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLB | down-regulates quantity
ubiquitination
|
SYK | 0.695 |
| Publications: | 1 | Organism: | Homo Sapiens | |