| + |
MKNK1 | down-regulates 
phosphorylation
|
SPRY2 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188889 |
Ser112 |
APLSRSIsTVSSGSR |
Homo sapiens |
|
| pmid |
sentence |
| 19864419 |
The spry2/nedd4 association involves the ww domains of nedd4 and requires phosphorylation of the mnk2 kinase sites, ser(112) and ser(121), on spry2. mnk2 silencing decreased spry2-nedd4 interactions and also augmented the ability of spry2 to inhibit fibroblast growth factor signaling. endogenous and overexpressed nedd4 polyubiquitinate spry2 via lys(48) on ubiquitin and decrease its stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188893 |
Ser121 |
VSSGSRSsTRTSTSS |
Homo sapiens |
|
| pmid |
sentence |
| 19864419 |
The spry2/nedd4 association involves the ww domains of nedd4 and requires phosphorylation of the mnk2 kinase sites, ser(112) and ser(121), on spry2. mnk2 silencing decreased spry2-nedd4 interactions and also augmented the ability of spry2 to inhibit fibroblast growth factor signaling. endogenous and overexpressed nedd4 polyubiquitinate spry2 via lys(48) on ubiquitin and decrease its stability. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MKNK1 | up-regulates 
phosphorylation
|
EIF4E |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157533 |
Ser209 |
DTATKSGsTTKNRFV |
Homo sapiens |
|
| pmid |
sentence |
| 17724079 |
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and mnk-mediated eukaryotic translation initiation factor 4e phosphorylation.Therefore, eif4e is considered a survival protein involved in cell cycle progression, cell transformation, and apoptotic resistance. Phosphorylation of eif4e (usually at ser209) increases its binding affinity for the cap of mrna and may also favor its entry into initiation complexes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9878069 |
Mnk1 and mnk2 regulate protein synthesis by phosphorylating the initiation factor eif4e. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166646 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Mnk1 and mnk2 regulate protein synthesis by phosphorylating the initiation factor eif4e. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | PI3K/AKT Signaling |
| + |
SGK1 | down-regulates activity
phosphorylation
|
MKNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277357 |
Ser352 |
SEAKDLIsKLLVRDA |
in vitro |
|
| pmid |
sentence |
| 28545025 |
We show that SGK1 phosphorylates MNK1 at a conserved site, which represses its activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277357 |
Ser353 |
S-->K |
in vitro |
|
| pmid |
sentence |
| 28545025 |
We show that SGK1 phosphorylates MNK1 at a conserved site, which represses its activity. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
PAK2 | down-regulates activity
phosphorylation
|
MKNK1 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250221 |
Ser39 |
RRGRATDsLPGKFED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15234964 |
Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. When 293T cells are subjected to apoptotic induction by hydrogen peroxide, Mnk1 is phosphorylated at both Thr(22) and Ser(27). These results indicate a role for Pak2 in the down-regulation of translation initiation in apoptosis by phosphorylation of Mnk1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MKNK1 | up-regulates activity
phosphorylation
|
PNPLA8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273677 |
Ser511 |
ELYRKLGsDVFSQNV |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 23258543 |
Constitutively active MNK1 activates and phosphorylates iPLA2γ. Thus, complement-mediated activation of iPLA(2)γ is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)γ. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MKNK1 | up-regulates activity
phosphorylation
|
PLA2G4A |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226633 |
Ser727 |
RQNPSRCsVSLSNVE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10978317 |
The results suggest that MNK1 or a closely related kinase is responsible for in vivo phosphorylation of cPLA2 on Ser-727. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates
dephosphorylation
|
MKNK1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168310 |
Thr250 |
NSCTPITtPELTTPC |
Homo sapiens |
|
| pmid |
sentence |
| 20927323 |
Moreover, a dephosphorylation assay revealed that pp2a could directly dephosphorylate mnk1 and eif4e. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168314 |
Thr255 |
ITTPELTtPCGSAEY |
Homo sapiens |
|
| pmid |
sentence |
| 20927323 |
Moreover, a dephosphorylation assay revealed that pp2a could directly dephosphorylate mnk1 and eif4e. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | PI3K/AKT Signaling |
| + |
ERK1/2 | up-regulates activity
phosphorylation
|
MKNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253014 |
Thr250 |
NSCTPITtPELTTPC |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17130135 |
We generated a phosphospecific antibody to Thr(P)-214 in the T-loop of MNKs and found that phosphorylations of both Thr-209 and Thr-214 in human MNK1 are required for activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253015 |
Thr255 |
ITTPELTtPCGSAEY |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17130135 |
We generated a phosphospecific antibody to Thr(P)-214 in the T-loop of MNKs and found that phosphorylations of both Thr-209 and Thr-214 in human MNK1 are required for activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253013 |
|
|
in vitro |
|
| pmid |
sentence |
| 9155018 |
These results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | PI3K/AKT Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MKNK1 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48342 |
Thr250 |
NSCTPITtPELTTPC |
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
Mnk1, but not mnk2, also binds strongly to the stress-activated kinase, p38. Erk and p38 phosphorylate MNK1 and Mnk2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253011 |
|
|
in vitro |
|
| pmid |
sentence |
| 9155018 |
These results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
MAPK14 | up-regulates
phosphorylation
|
MKNK1 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48346 |
Thr255 |
ITTPELTtPCGSAEY |
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
Mnk1, but not mnk2, also binds strongly to the stress-activated kinase, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
MKNK1 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48360 |
Thr385 |
APEKGLPtPQVLQRN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9155018 |
Mnk1 was phosphorylated and activated in vitro by erk1 and p38 map kinasespreliminary results showed that thr344 at least was one of the major sites phosphorylated by erk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
We have identified a new subfamily of murine serine/threonine kinases, whose members, map kinase-interacting kinase 1 (mnk1) and mnk2, bind tightly to the growth factor-regulated map kinases, erk1 and erk2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
MKNK1 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253012 |
|
|
in vitro |
|
| pmid |
sentence |
| 9155018 |
These results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK1 | up-regulates
phosphorylation
|
MKNK1 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
We have identified a new subfamily of murine serine/threonine kinases, whose members, map kinase-interacting kinase 1 (mnk1) and mnk2, bind tightly to the growth factor-regulated map kinases, erk1 and erk2erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4e (eif-4e). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
MKNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270022 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9155018 |
Mnk1 was phosphorylated and activated in vitro by erk1 and p38 map kinasespreliminary results showed that thr344 at least was one of the major sites phosphorylated by erk1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Tomivosertib | down-regulates activity
chemical inhibition
|
MKNK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261116 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29526098 |
Compound 23 (eFT508), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MKNK1
- 
- 