3.0
Summary
| Name |  NUAK1View Modifications |
| Full Name | NUAK family SNF1-like kinase 1 |
| Synonyms | AMPK-related protein kinase 5, ARK5, Omphalocele kinase 1 | ARK5, KIAA0537, OMPHK1 |
| Primary ID | O60285 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1 |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NUAK1 | up-regulates 
phosphorylation
|
TP53 | 0.527 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | NUAK1 | down-regulates activity 
phosphorylation
|
CASP6 | 0.497 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NUAK1 | down-regulates
phosphorylation
|
PPP1R12A | 0.522 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | NUAK1 | down-regulates
phosphorylation
|
LATS1 | 0.397 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | up-regulates
phosphorylation
|
NUAK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates
phosphorylation
|
NUAK1 | 0.266 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK11 | up-regulates
phosphorylation
|
NUAK1 | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |