Summary

Name FZD6
Full Name Frizzled-6
Synonyms Fz-6, hFz6
Primary ID O60353
Links - -
Type protein
Relations 6
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ FZD6up-regulates activity img/direct-activation.png binding DVL1 0.666
Publications: 1 Organism: Homo Sapiens
+ WNT5Aup-regulates activity img/direct-activation.png binding FZD6 0.686
Publications: 1 Organism: Homo Sapiens
+ WNT11up-regulates activity img/direct-activation.png binding FZD6 0.66
Publications: 1 Organism: Homo Sapiens
+ WNT1up-regulates activity img/direct-activation.png binding FZD6 0.68
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ ZNRF3down-regulates quantity img/direct_inhibition.png ubiquitination FZD6 0.597
Publications: 1 Organism: Homo Sapiens
+ WNT5Bup-regulates img/direct-activation.png binding FZD6 0.655
Publications: 1 Organism: Homo Sapiens