Relation Results

Summary

Name WNT5B
Full Name Protein Wnt-5b
Synonyms WNT5B_HUMAN
Primary ID Q9H1J7
Links - -
Type protein
Relations 7
Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects ...
View More

Viewer

Type: Score: Layout: SPV 
0.6330.5870.2780.2540.6650.625WNT5BFZD3LRP5SOSTDC1PPARGFZD6LRP6

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ WNT5Bup-regulates img/direct-activation.png binding FZD3 0.633
Identifier Residue Sequence Organism Cell Line
SIGNOR-131882 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-141440 Homo sapiens Lung Cancer Cell, Melanoma Cell
pmid sentence
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors.
Publications: 2 Organism: Homo Sapiens
+ WNT5Bup-regulates img/direct-activation.png binding LRP5 0.587
Identifier Residue Sequence Organism Cell Line
SIGNOR-131885 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
+ SOSTDC1down-regulates activity img/indirect_inhibition.png WNT5B 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-242727 Mus musculus
pmid sentence
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells.
Publications: 1 Organism: Mus Musculus
+ WNT5Bup-regulates img/indirect-activation.png PPARG 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-186625 Homo sapiens
pmid sentence
Wnt5b additionally appears to be a potent enhancer of adipogenic capacity by stimulation of ppargamma
Publications: 1 Organism: Homo Sapiens
+ WNT5Bup-regulates img/direct-activation.png binding FZD6 0.665
Identifier Residue Sequence Organism Cell Line
SIGNOR-141443 Homo sapiens Lung Cancer Cell, Melanoma Cell
pmid sentence
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors.
Publications: 1 Organism: Homo Sapiens
+ WNT5Bup-regulates img/direct-activation.png binding LRP6 0.625
Identifier Residue Sequence Organism Cell Line
SIGNOR-131888 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
a simple tooltip