Relation Results

Summary

Name PTP4A3
Full Name Protein tyrosine phosphatase type IVA 3
Synonyms PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3 | PRL3
Primary ID O75365
Links - -
Type protein
Relations 5
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive ...
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Type: Score: Layout: SPV 
0.2750.280.5070.3PTP4A3KRT8EZRITGB1PTEN

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PTP4A3down-regulates activity img/direct_inhibition.png dephosphorylation KRT8 0.275
Identifier Residue Sequence Organism Cell Line
SIGNOR-248341 Ser432 SAYGGLTsPGLSYSL Homo sapiens Colonic Cancer Cell
pmid sentence
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431
Identifier Residue Sequence Organism Cell Line
SIGNOR-248340 Ser74 TVNQSLLsPLVLEVD Homo sapiens Colonic Cancer Cell
pmid sentence
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431|The site-specific phosphorylation of keratins induces the disassembly of these filaments, and the balance between their phosphorylation and dephosphorylation controls the continuous exchange of intermediate filament subunits between a soluble pool and polymerized filaments
Publications: 2 Organism: Homo Sapiens
+ PTP4A3down-regulates activity img/direct_inhibition.png dephosphorylation EZR 0.28
Identifier Residue Sequence Organism Cell Line
SIGNOR-248342 Thr567 QGRDKYKtLRQIRQG Homo sapiens HCT-116 Cell
pmid sentence
Here we report the identification of Ezrin as a specific and direct cellular substrate of PRL-3. In HCT116 colon cancer cell line, Ezrin was identified among the cellular proteins whose phosphorylation level decreased upon ectopic over-expression of wtPRL-3 but not of catalytically inactive PRL-3 mutants. Although PRL-3 over-expression in HCT116 cells appeared to affect Ezrin phosphorylation status at both tyrosine residues and Thr567, suppression of the endogenous protein by RNA interference pointed to Ezrin-Thr567 as the residue primarily affected by PRL-3 action.
Publications: 1 Organism: Homo Sapiens
+ PTP4A3down-regulates activity img/direct_inhibition.png dephosphorylation ITGB1 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-277050 Tyr783 DTGENPIyKSAVTTV Homo sapiens
pmid sentence
In this study, we demonstrate that PRL-3 directly binds to integrin \u03b21 and dephosphorylates integrin \u03b21-Y783, a key residue for integrin \u03b21 function [ ].|These results indicate that PRL-3 dephosphorylates integrin \u03b21 in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ PTP4A3down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation PTEN 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-277010 Homo sapiens
pmid sentence
As expected, PRL3 clearly reduced PTEN phosphorylation at the tyrosine residue and PTEN protein in PRL3 overexpressing LO2 and HepG2 cell lines, with no significant changes in PRL3 (C104S) mutant cells.|PRL3 down-regulates PTEN expression, a negative regulator of the Akt pathway.11 Phosphorylation of PTEN at Tyr336 is required for maintenance of PTEN protein stability and prevention of PTEN degradation.17 We therefore speculated that PRL3 might dephosphorylate PTEN at tyrosine sites and consequently reduce the PTEN protein level.
Publications: 1 Organism: Homo Sapiens
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