Summary

Name PRDM1
Full Name PR domain zinc finger protein 1
Synonyms BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, Positive regulatory domain I-binding factor 1, PRDI-BF1, PRDI-binding factor 1 | BLIMP1
Primary ID O75626
Links - -
Type protein
Relations 11
Function Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png sumoylation PRDM1 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAX5 0.525
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYC 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation PRDM1 0.525
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation PAX5 0.525
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FCER2 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CCL2 0.2
Publications: 1
+ up-regulates img/indirect-activation.png Pluripotency 0.7
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYC 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CIITA 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRDM1 0.375
Publications: 1