| + |
IRF4 | up-regulates quantity by expression 
transcriptional regulation
|
FCER2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253933 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11342629 |
IFN-regulatory factor 4 (IRF-4) plays a critical role in mature B cell function. Using the transcriptional regulation of the human B cell activation marker CD23 as a model system, we have previously demonstrated that IRF-4 is induced in response to B cell-activating stimuli and that it acts as a transactivator of CD23 gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | down-regulates quantity by repression 
transcriptional regulation
|
FCER2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254277 |
|
|
Homo sapiens |
RAMOS Cell |
| pmid |
sentence |
| 9300687 |
Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule. In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRDM1 | down-regulates quantity by repression
transcriptional regulation
|
FCER2 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253926 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11342629 |
In this study, we report that PRDI-BF1/Blimp1 can bind to the same functional element in the human CD23b promoter to which BCL-6 and IRF-4 had previously been shown to bind, and that, like BCL-6, Blimp1 can repress IRF-4-transactivating ability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL6 | down-regulates quantity by repression
transcriptional regulation
|
FCER2 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253928 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11342629 |
In this study, we report that PRDI-BF1/Blimp1 can bind to the same functional element in the human CD23b promoter to which BCL-6 and IRF-4 had previously been shown to bind, and that, like BCL-6, Blimp1 can repress IRF-4-transactivating ability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FCER2
- 
- 