| + |
GNB5 | down-regulates activity 
binding
|
ADCY5 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264998 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
The D2-class dopamine receptors (D2, D3, and D4) couple to the Gi/o family of G proteins and thus induce inhibition of AC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
ADCY5 | up-regulates quantity 
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
NF1 | up-regulates 
|
ADCY5 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204140 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24431436 |
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI1 | down-regulates activity
binding
|
ADCY5 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278074 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 8119955 |
Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
| + |
GNAL | up-regulates activity
binding
|
ADCY5 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264997 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
GNAZ | down-regulates activity
binding
|
ADCY5 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278045 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 7829508 |
Activated a z inhibits the activity of type I and type V adenylyl cyclases. |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
| + |
GNB/GNG | down-regulates activity
binding
|
ADCY5 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278046 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 9707174 |
These results demonstrate that adenylyl cyclase types V and Vi are inhibited by Gbetagamma dimers. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY5 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278075 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 8119955 |
Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
| + |
GNAI3 | down-regulates activity
binding
|
ADCY5 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278076 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 8119955 |
Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
3.0
ADCY5
- 
- 