| + |
GNAL | up-regulates activity 
binding
|
ADCY5 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264997 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
NF1 | up-regulates 
|
ADCY5 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204140 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24431436 |
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY5 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
GNB5 | down-regulates activity 
binding
|
ADCY5 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264998 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
The D2-class dopamine receptors (D2, D3, and D4) couple to the Gi/o family of G proteins and thus induce inhibition of AC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
3.0
ADCY5
- 
- 