Summary

Name GNB5
Full Name Guanine nucleotide-binding protein subunit beta-5
Synonyms Gbeta5, Transducin beta chain 5 |
Primary ID O14775
Links - -
Type protein
Relations 7
Pathways Dopaminergic Synapse, GABAergic synapse , Oxytocin signaling
Function Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ GNB5down-regulates activity img/direct_inhibition.png binding ADCY5 0.426
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ GNB5down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.453
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ DRD3up-regulates activity img/direct-activation.png binding GNB5 0.421
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ DRD4up-regulates activity img/direct-activation.png binding GNB5 0.432
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ DRD2up-regulates activity img/direct-activation.png binding GNB5 0.581
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse, Oxytocin signaling
+ GNB5down-regulates activity img/direct_inhibition.png binding ADCY1 0.426
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ GABA-B receptorup-regulates activity img/direct-activation.png binding GNB5 0.455
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse