Summary

Name TGFA
Full Name Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha
Synonyms TGFA_HUMAN
Primary ID P01135
Links - -
Type protein
Relations 6
Pathways EGFR
Function TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding EGFR
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/indirect-activation.png unknown Angiogenesis
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFA 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFA 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown TGFA 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png cleavage TGFA 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR