| + |
CSNK2A2 |
phosphorylation
|
MYCN |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251014 |
Ser261 |
TSGEDTLsDSDDEDD |
in vitro |
|
| pmid |
sentence |
| 1425701 |
Analysis of phosphorylation sites in synthetic peptides of this acidic region identified the major sites phosphorylated by CKII as Ser261 and Ser263. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251015 |
Ser263 |
GEDTLSDsDDEDDEE |
in vitro |
|
| pmid |
sentence |
| 1425701 |
Analysis of phosphorylation sites in synthetic peptides of this acidic region identified the major sites phosphorylated by CKII as Ser261 and Ser263. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
CSNK2A1 |
phosphorylation
|
MYCN |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250920 |
Ser261 |
TSGEDTLsDSDDEDD |
in vitro |
|
| pmid |
sentence |
| 1425701 |
Analysis of phosphorylation sites in synthetic peptides of this acidic region identified the major sites phosphorylated by CKII as Ser261 and Ser263. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250921 |
Ser263 |
GEDTLSDsDDEDDEE |
in vitro |
|
| pmid |
sentence |
| 1425701 |
Analysis of phosphorylation sites in synthetic peptides of this acidic region identified the major sites phosphorylated by CKII as Ser261 and Ser263. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
MYCN |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279722 |
Thr58 |
KKFELLPtPPLSPSR |
Homo sapiens |
|
| pmid |
sentence |
| 20530674 |
Because GSK3\u03b2 phosphorylates Nmyc at T58, we assessed GSK3\u03b2 activation in Dex-treated MB cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | up-regulates quantity by expression 
transcriptional regulation
|
MYCN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254215 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
HOXA9/HOXA10 activated expression of NMYC which in turn mediated MEF2C repression, indicating an indirect mode of regulation via NMYC interactor (NMI) and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCN | down-regulates quantity by repression 
transcriptional regulation
|
ABCB1 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254616 |
|
|
Homo sapiens |
SH-SY5Y Cell, BE(2)-M17 Cell |
| pmid |
sentence |
| 7923112 |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI3 | down-regulates quantity by repression
transcriptional regulation
|
MYCN |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188881 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
Gli activators bind to gaccaccca motif to regulate transcription of gli1, ptch1, ptch2, hhip1, mycn, ccnd1, ccnd2, bcl2, cflar, foxf1, foxl1, prdm1 (blimp1), jag2, grem1, and follistatin. .Hedgehog Signals induce cellular proliferation through upregulation of n-myc, cyclin d/e, and foxm1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
Gli activators bind to gaccaccca motif to regulate transcription of gli1, ptch1, ptch2, hhip1, mycn, ccnd1, ccnd2, bcl2, cflar, foxf1, foxl1, prdm1 (blimp1), jag2, grem1, and follistatin. .Hedgehog Signals induce cellular proliferation through upregulation of n-myc, cyclin d/e, and foxm1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
MYCN |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188872 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
MYCN |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278750 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33628735 |
HUWE1 ubiquitinates and directs MYCN degradation to the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI1/GLI2 | up-regulates quantity by expression 
transcriptional regulation
|
MYCN |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269212 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 32766732 |
GLI1 and GLI2 were shown to co-immunoprecipitate in PANC1 pancreatic cancer cells and RMS13 rhabdomyosarcoma cells.|Chromatin immunoprecipitation showed that GLI1 and GLI2 occupied the same regions at the BCL2, MYCN and CCND1 promoters. Furthermore, depletion of GLI1 inhibited GLI2 occupancy at these promoters, suggesting that GLI1/GLI2 interaction is required for the recruitment of GLI2 to these sites. | RNAi knockdown of either GLI1 or GLI2 inhibited expression of many well-characterized GLI target genes (BCL2, MYCN, PTCH2, IL7 and CCND1) in PANC1 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCN | up-regulates quantity by expression
transcriptional regulation
|
CTSD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18566016 |
In primary neuroblastomas, high CTSD messenger RNA (mRNA) levels were associated with amplified MYCN, a strong predictive marker of adverse outcome. Chromatin immunoprecipitation and luciferase promoter assays revealed that MYCN protein binds to the CTSD promoter and activates its transcription, suggesting a direct link between deregulated MYCN and CTSD mRNA expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCN | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254214 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
HOXA9/HOXA10 activated expression of NMYC which in turn mediated MEF2C repression, indicating an indirect mode of regulation via NMYC interactor (NMI) and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-326 | down-regulates quantity by repression
post transcriptional regulation
|
MYCN |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277980 |
|
|
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 25173582 |
The upregulation of miR-326 not only inhibited the activity of the Hh pathway but also reduced the expression of additional Hh signaling components, including GLI1, N-myc, and CyclinD1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCN | up-regulates quantity by expression
transcriptional regulation
|
ABCC1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7923112 |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX17/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
MYCN |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269257 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
MYCN | up-regulates quantity by expression
transcriptional regulation
|
SIRT2 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255145 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 23175188 |
Here we demonstrated that the class III histone deacetylase SIRT2 was upregulated by N-Myc in neuroblastoma cells and by c-Myc in pancreatic cancer cells, and that SIRT2 enhanced N-Myc and c-Myc protein stability and promoted cancer cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT2 | up-regulates quantity by stabilization
|
MYCN |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23175188 |
Here we demonstrated that the class III histone deacetylase SIRT2 was upregulated by N-Myc in neuroblastoma cells and by c-Myc in pancreatic cancer cells, and that SIRT2 enhanced N-Myc and c-Myc protein stability and promoted cancer cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA9 | up-regulates quantity by expression
transcriptional regulation
|
MYCN |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254213 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
HOXA9/HOXA10 activated expression of NMYC which in turn mediated MEF2C repression, indicating an indirect mode of regulation via NMYC interactor (NMI) and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MYCN
- 
- 