| + |
DBP | up-regulates quantity by expression 
transcriptional regulation
|
ALDOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253833 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DBP | up-regulates
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
In addition to NHRs, Dbp, a known clock target gene, regulates expression of key metabolic genes involved in gluconeogenesis and lipogenesis (60). Because DBP levels change 100-fold in response to CLOCK/BMAL1 activation, it is conceivable that DBP generates circadian oscillation in metabolic processes such as gluconeogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CLOCK/BMAL1 | up-regulates quantity by expression 
transcriptional regulation
|
DBP |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268029 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 30100984 |
The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression. Gene expression of DBP itself is under the control of E-box-dependent binding by the Bmal1-Clock heterodimer and CRE-dependent binding by the cAMP responsive element binding protein (CREB). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| Pathways: | Circadian clock |
| + |
DBP | up-regulates quantity by expression
transcriptional regulation
|
CYP3A4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253835 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18004209 |
The oscillation in the expression of the CYP3A4 gene seemed to be the underlying cause of the rhythmic change in its metabolic activity. Luciferase reporter gene analysis and electrophoretic mobility shift assay revealed that the circadian transcriptional factor, D-site-binding protein (DBP), activated the transcription of the CYP3A4 gene by binding to the DNA sequence near the upstream of the transcriptional start site. The transactivation of the CYP3A4 gene by DBP was repressed by the E4 promoter-binding protein-4 (E4BP4), a negative component of the circadian clock. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DBP | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270225 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DBP | up-regulates quantity by expression
transcriptional regulation
|
CYP7A1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254121 |
|
|
|
|
| pmid |
sentence |
| 8617210 |
While TEF stimulates transcription from the albumin promoter more potently than DBP, only DBP is capable of activating transcription efficiently from the cholesterol 7 alpha hydroxylase (C7alphaH) promoter. |
|
| Publications: |
1 |
3.0
DBP
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